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Literature summary for 3.5.1.98 extracted from

  • Buckwalter, J.M.; Chan, W.; Shuman, L.; Wildermuth, T.; Ellis-Mohl, J.; Walter, V.; Warrick, J.I.; Wu, X.R.; Kaag, M.; Raman, J.D.; DeGraff, D.J.
    Characterization of histone deacetylase expression within in vitro and in vivo bladder cancer model systems (2019), Int. J. Mol. Sci., 20, E2599 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene HDAC4, histone deacetylase expression within in vitro and in vivo bladder cancer model systems, quantitative real-time PCR enzyme expression analysis, overview. Basal-squamous bladder cancer (BC) clinical samples are enriched for histone deacetylase (HDAC)4 and HDAC9 expression Homo sapiens
gene HDAC7, histone deacetylase expression within in vitro and in vivo bladder cancer model systems, quantitative real-time PCR enzyme expression analysis, overview Homo sapiens
gene HDAC9, histone deacetylase expression within in vitro and in vivo bladder cancer model systems, quantitative real-time PCR enzyme expression analysis, overview. Basal-squamous bladder cancer clinical samples are enriched for histone deacetylase (HDAC)4 and HDAC9 expression Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P56524
-
-
Homo sapiens Q8WUI4
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Homo sapiens Q9UKV0
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-

Source Tissue

Source Tissue Comment Organism Textmining
HT-1197 cell
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 Homo sapiens
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HT-1376 cell
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 Homo sapiens
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additional information quantitative real-time PCR enzyme expression analysis, high expression of class IIa HDACs in non-type and basal molecular subtype groupings of human BC cells Homo sapiens
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RT-4 cell
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 Homo sapiens
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SCaBER 5637 cell
-
 Homo sapiens
-
SW-780 cell
-
 Homo sapiens
-
T-24 cell
-
 Homo sapiens
-
TCC-SUP cell
-
 Homo sapiens
-
UM-UC-1 cell
-
 Homo sapiens
-
UM-UC-3 cell
-
 Homo sapiens
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urinary bladder cancer cell class I and class IIa histone deacetylases (HDACs) are overexpressed in non-type and basal human bladder cancer (BC) cell lines at the mRNA level, overview Homo sapiens
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urinary bladder cancer cell class I and class IIa histone deacetylases (HDACs) are overexpressed in non-type and basal human bladder cancer cell lines at the mRNA level, overview. Basal-squamous bladder cancer (BC) clinical samples are enriched for histone deacetylase (HDAC)4 and HDAC9 expression. Histone deacetylase (HDAC4) and HDAC9 expression co-clusters with basal markers in muscle-invasive bladder cancer Homo sapiens
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Synonyms

Synonyms Comment Organism
class IIa HDAC
-
 Homo sapiens
HDAC4
-
 Homo sapiens
HDAC7
-
 Homo sapiens
HDAC9
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism epigenetic modifications including DNA methylation and histone post-translational modifications are closely associated with bladder cancer (BC) initiation and development, some HDACs play roles in the tumorigenicity of bladder cancer, overview. HDAC4 and HDAC9 expression is inversely correlated with Forkhead Box A1 (FOXA1), an important transcription factor in maintaining urothelial differentiation, and peroxisome proliferator-activated receptor gamma (PPARG), a steroid hormone receptor known for its oncogenic role in the development of BC Homo sapiens
metabolism epigenetic modifications including DNA methylation and histone post-translational modifications are closely associated with bladder cancer initiation and development, some HDACs play roles in the tumorigenicity of bladder cancer, overview Homo sapiens
physiological function increased expression of HDAC4 and -9 in patients with invasive squamous cell carcinoma supporting the idea that class IIa HDACs are important in the development of a basal molecular subtype and squamous differentiation in bladder cancer Homo sapiens
physiological function increased expression of HDAC4 and HDAC9 in patients with invasive squamous cell carcinoma supporting the idea that class IIa HDACs are important in the development of a basal molecular subtype and squamous differentiation in bladder cancer Homo sapiens