Application | Comment | Organism |
---|---|---|
drug development | the enzyme might be a promising target for the development of novel anti-babesial drugs | Babesia bovis |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination and analysis, sequence comparisons, recombinant expression of GST-tagged isozyme HDAC3 in Escherichia coli | Babesia bovis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cyclo (N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl-L-2-amino-8-oxodecanoyl) | i.e. apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity, inhibits the enzyme activity as well as the in vitro growth of Babesia parasites with an IC50 of 3.8 ng/ml | Babesia bovis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | required, enzyme bound | Babesia bovis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
51200 | - |
x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
77200 | - |
x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Babesia bovis | - |
isozyme HDAC3 | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 51200, isozyme HDAC3, SDS-PAGE, x * 77200, recombinant GST-tagged isozyme HDAC3, SDS-PAGE | Babesia bovis |
Synonyms | Comment | Organism |
---|---|---|
HDAC | - |
Babesia bovis |
HDAC 3 | - |
Babesia bovis |
HDAC3 | - |
Babesia bovis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Babesia bovis |