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Literature summary for 3.5.1.98 extracted from
- The specific role of histone deacetylase 2 in adult neurogenesis (2010), Neuron Glia Biol., 6, 93-107.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HDAC2 | - |
Mus musculus |
| histone deacetylase 2 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | while brain development and adult stem cell fate are normal upon conditional deletion of HDAC2 or in mice lacking the catalytic activity of HDAC2, neurons derived from both zones of adult neurogenesis die at a specific maturation stage | Mus musculus |
| physiological function | the catalytic function of HDAC2 is required in adult but not embryonic neurogenesis. HDAC2 is critically required to silence progenitor transcripts during neuronal differentiation of adult generated neurons | Mus musculus |
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Release 2023.1 (January 2023)
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