Literature summary for 3.5.1.98 extracted from

Tennen, R.I.; Berber, E.; Chua, K.F.
Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization (2010), Mech. Ageing Dev., 131, 185-192.

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Organism

Organism	UniProt	Comment	Textmining

General Information

General Information	Comment	Organism
physiological function	SIRT6 is a site-specific histone deacetylase that regulates chromatin structure. SIRT6 is implicated in fundamental biological processes in aging, including maintaining telomere integrity, fine-tuning aging-associated gene expression programs, preventing genomic instability, and maintaining metabolic homeostasis. The N-terminal extension of SIRT6 is critical for chromatin association and intrinsic catalytic activity	Homo sapiens

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Release 2023.1 (January 2023)