Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha-keto-gamma-methylselenobutyrate | causes dose-dependent inhibition of HDAC activity, HDAC1 shows about 80% residual activity at 2 mM, HDAC8 shows less than 60% residual activity at 2 mM | Homo sapiens | |
beta-methylselenopyruvate | causes dose-dependent inhibition of HDAC activity, competitive inhibitor of HDAC8, HDAC1 shows about 30% residual activity at 2 mM, HDAC8 shows less than 30% residual activity at 2 mM | Homo sapiens | |
Butyrate | - |
Homo sapiens | |
additional information | methylselenocysteine and selenomethionine have little or no inhibitory activity up to 2 mM | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9BY41 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
colonic cancer cell | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
HT-29 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-histone H3 + H2O | - |
Homo sapiens | acetate + histone H3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HDAC1 | - |
Homo sapiens |
HDAC8 | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02 | - |
HDAC8, at 37°C, pH not specified in the publication | Homo sapiens | beta-methylselenopyruvate |