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Literature summary for 3.5.1.98 extracted from

  • Liu, R.; Wang, L.; Chen, G.; Katoh, H.; Chen, C.; Liu, Y.; Zheng, P.
    FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus (2009), Cancer Res., 69, 2252-2259.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
FOXP FOXP3 specifically inhibits binding of histone deacetylase 2 and 4 to the site and increases local histone H3 acetylation Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-lysine-histone H3 + H2O
-
Homo sapiens acetate + histone H3
-
?

Synonyms

Synonyms Comment Organism
HDAC2
-
Homo sapiens
HDAC4
-
Homo sapiens
histone deacetylase 2
-
Homo sapiens
histone deacetylase 4
-
Homo sapiens

General Information

General Information Comment Organism
malfunction short hairpin-RNA silencing of either HDAC2 or HDAC4 is sufficient to induce p21 expression Homo sapiens