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Literature summary for 3.5.1.98 extracted from

  • Kawabata, T.; Nishida, K.; Takasugi, K.; Ogawa, H.; Sada, K.; Kadota, Y.; Inagaki, J.; Hirohata, S.; Ninomiya, Y.; Makino, H.
    Increased activity and expression of histone deacetylase 1 in relation to tumor necrosis factor-alpha in synovial tissue of rheumatoid arthritis (2010), Arthritis Res. Ther., 12, R133.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
trichostatin A
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
synovial tissue
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HDAC
-
 Homo sapiens
histone deacetylase 1
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens nuclear HDAC activity is significantly higher in rheumatoid arthritis than in osteoarthritis and normal controls. The mRNA expression of HDAC1 in rheumatoid arthritis synovial tissue is higher than in osteoarthritis and normal controls, and shows positive correlation with tumor necrosis factor-alpha mRNA expression. Stimulation with tumor necrosis factor-alpha (10 ng/ml) significantly increases the nuclear HDAC activity and HDAC1 mRNA expression at 24 h and HDAC1 protein expression at 48 h in synovial fibroblasts from rheumatoid arthritis up