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Literature summary for 3.5.1.98 extracted from

  • Xiong, S.D.; Yu, K.; Liu, X.H.; Yin, L.H.; Kirschenbaum, A.; Yao, S.; Narla, G.; Difeo, A.; Wu, J.B.; Yuan, Y.; Ho, S.M.; Lam, Y.W.; Levine, A.C.
    Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone deacetylase-1 selectively in premalignant and malignant prostate cancer cells (2009), Int. J. Cancer, 125, 774-782.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.98

Application

Application Comment Organism
medicine type I ribosome-inactivating proteins derived from plants are HDAC inhibitors that can be utilized in the prevention and treatment of prostate cancer Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
MCP30 30 kDa protein isolated from bitter melon seeds, Momordica charantia, contains two highly related type I ribosome-inactivating proteins, alpha- and beta-momorcharin Homo sapiens
trichostatin A
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens histone deacetylases catalyze the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13547
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
prostate cancer cell line
-
 Homo sapiens
-
prostate gland intraepithelial neoplasia cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information histone deacetylases catalyze the removal of acetyl groups from histones, leading to chromatin condensation and transcriptional repression Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
histone deacetylase-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Homo sapiens