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Literature summary for 3.5.1.98 extracted from

  • Han, A.; He, J.; Wu, Y.; Liu, J.O.; Chen, L.
    Mechanism of recruitment of class II histone deacetylases by myocyte enhancer factor-2 (2004), J. Mol. Biol., 345, 91-102.
    View publication on PubMed
Search for more literature for 3.5.1.98

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
complex of isoform HDAC9 with myocyte enhancer factor-2 and DNA. HDAC9 binds to a hydrophobic groove of the myocyte enhancer factor-2 dimer. General mechainsm, by which class II histone deacetylases are recruited by myocyte enhancer factor-2 Homo sapiens

Protein Variants

Protein Variants Comment Organism
L175A mutation in fragment 155-220 of isoform HDAC4, binding to myocyte enhancer factor-2 is diminished Homo sapiens
L175K mutation in fragment 155-220 of isoform HDAC4, binding to myocyte enhancer factor-2 is diminished Homo sapiens
L180A mutation in fragment 155-220 of isoform HDAC4, little effect on binding to myocyte enhancer factor-2 Homo sapiens
L180K mutation in fragment 155-220 of isoform HDAC4, little effect on binding to myocyte enhancer factor-2 Homo sapiens
V171A mutation in fragment 155-220 of isoform HDAC4, little effect on binding to myocyte enhancer factor-2 Homo sapiens
V171K mutation in fragment 155-220 of isoform HDAC4, binding to myocyte enhancer factor-2 is diminished Homo sapiens
V179A mutation in fragment 155-220 of isoform HDAC4, binding to myocyte enhancer factor-2 is diminished Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Subunits

Subunits Comment Organism
More class II histone deacetylases bind myocyte enhancer factor-2 Homo sapiens