Cloned (Comment) | Organism |
---|---|
isoform HDAC3, expression in NIH 3T3 fibroblasts | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-histone H4 + H2O | Mus musculus | - |
acetate + histone H4 | rate of deacetylation is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
isoform HDAC3 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N-acetyl-lysine-histone H3 + H2O | - |
Mus musculus | acetate + histone H3 | individual lysine residues in the H3 tail are deacetylated at similar rates | ? | |
N-acetyl-lysine-histone H4 + H2O | - |
Mus musculus | acetate + histone H4 | rate of deacetylation is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other | ? | |
N-acetyl-lysine-histone H4 + H2O | - |
Mus musculus | acetate + histone H4 | rate of deacetylation by isoform HDAC3 is not uniform. H4 K5 is deacetylated first, followed by K8, K12 and K16. The specificity of deacetylation and the histone-binding preference of transcriptional co-repressors N-CoR/SMRT match each other | ? |