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Literature summary for 3.5.1.93 extracted from

  • Kim, Y.; Hol, W.G.
    Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity (2001), Chem. Biol., 8, 1253-1264.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
ligand bound enzyme crystals grow at 21°C from hanging drops, binary complex structure of the enzyme with glutaryl-7-aminocephalosporanic acid and glutarate solved at 2.6 A and 2.5 A resolution, respectively, shows extensive interactions between the glutaryl moiety of glutaryl-7-aminocephalosporanic acid and the seven residues that form the side-chain pocket Brevundimonas diminuta
vapour diffusion method. Binary complex structures with glutarate and glutaryl-7-aminocephalosporanic acid, solved at 2.6 A and 2.5 A resolution, respectively Brevundimonas diminuta

Organism

Organism UniProt Comment Textmining
Brevundimonas diminuta Q9L5D6
-
-
Brevundimonas diminuta Q9L5D6 KAC-1
-
Brevundimonas diminuta KAC-1 Q9L5D6 KAC-1
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutaryl-7-aminocephalosporanic acid + H2O
-
Brevundimonas diminuta 7-aminocephalosporanate + glutarate
-
?
glutaryl-7-aminocephalosporanic acid + H2O
-
Brevundimonas diminuta KAC-1 7-aminocephalosporanate + glutarate
-
?

Synonyms

Synonyms Comment Organism
7beta-(4-carboxybutanamido)cephalosporanic acid acylase
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Brevundimonas diminuta
CA
-
Brevundimonas diminuta
cephalosporin acylase
-
Brevundimonas diminuta
cephalosporin C acylase
-
Brevundimonas diminuta
GA
-
Brevundimonas diminuta
GCA
-
Brevundimonas diminuta
GL-7-ACA acylase
-
Brevundimonas diminuta
glutaryl-7-ACA acylase
-
Brevundimonas diminuta
glutaryl-7-aminocephalosporanic acid acylase
-
Brevundimonas diminuta