Literature summary for 3.5.1.92 extracted from

Sayasith, K.; Sirois, J.; Lussier, J.G.
Expression, regulation, and promoter activation of vanin-2 (VNN2) in bovine follicles prior to ovulation (2013), Biol. Reprod., 89, 98.

Search for more literature for 3.5.1.92

Cloned(Commentary)

Cloned (Comment)	Organism
gene VNN2, semiquantitative RT-PCR expression analysis in ovulatory follicles and granulosa cells, DNA-binding activity of bovine VNN2 promoter, overview	Bos taurus

Protein Variants

Protein Variants	Comment	Organism
additional information	construction of several VNN2 promoter-deletion mutants: deletion of the region between -1107 and -530 result in a marked and significant increase of basal and forskolin-stimulated promoter activities, suggesting factors repressing the promoter activity in this region. This region contains a number of consensus cis-acting elements of which COUP-TF, GATA, and Ebox appears to play a key role, as revealed by site-directed mutagenesis and promoter activity assays. Deletion between -530 and -262 markedly decreased basal and forskolin-stimulated promoter activities as compared to the-530VNN2.LUC construct. Further deletions do not change promoter activities, thus identifying the region -530/-262 as important in the regulation of the VNN2 promoter activity in bovine granulosa cells	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	A5D9D1	-	-
Bos taurus Holstein	A5D9D1	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
granulosa cell	regulation of VNN2 transcripts in bovine follicles prior to ovulation, high levels of gonadotropins regulate VNN2 mRNA expression in granulosa cells of bovine preovulatory follicles	Bos taurus	-
ovarian follicle	ovulatory, regulation of VNN2 transcripts in bovine follicles prior to ovulation, high expression level during the ovulatory process	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
vanin-2	-	Bos taurus
VNN2	-	Bos taurus

Expression

Organism	Comment	Expression
Bos taurus	VNN2 promoter activity and mRNA expression are inhibited by protein kinase A and ERK1/2 inhibitors	down
Bos taurus	VNN2 promoter activity and mRNA expression are markedly stimulated by forskolin and overexpression of the catalytic subunit of protein kinase A	up

General Information

General Information	Comment	Organism
physiological function	vanin-2 is known to be involved in inflammation and leukocyte migration	Bos taurus

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Release 2023.1 (January 2023)