Cloned (Comment) | Organism |
---|---|
vanin-1 is highly expressed in liver and is under transcriptional control of PPAR-alpha and nutritional statu | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(R)-2,4-dihydroxy-3,3-dimethyl-N-(3-oxo-4-phenylbutyl)butanamide | i.e. RR6, design, synthesis, and characterization of a novel pantetheine analogue, RR6, that acts as a selective, reversible, and competitive vanin inhibitor at nanomolar concentration. Oral administration of RR6 in rats completely inhibits plasma vanin activity and caused alterations of plasma lipid concentrations upon fasting | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-pantetheine + H2O | Rattus norvegicus | - |
(R)-pantothenate + 2-aminoethanethiol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | Q4KLZ0 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | vanin-1 is highly expressed in liver | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(R)-pantetheine + H2O | - |
Rattus norvegicus | (R)-pantothenate + 2-aminoethanethiol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
vanin-1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | vanins are enzymes with pantetheinase activity and are presumed to play a role in the recycling of pantothenic acid (vitamin B5) from pantetheine. Pantothenic acid is an essential nutrient required to synthesize coenzyme A, a cofactor involved in many biological processes such as fatty acid synthesis and oxidation of pyruvate to fuel the citric acid cycle. Hydrolysis of pantetheine also liberates cysteamine, a known antioxidant | Rattus norvegicus |