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Literature summary for 3.5.1.88 extracted from

  • Gao, J.; Wang, T.; Qiu, S.; Zhu, Y.; Liang, L.; Zheng, Y.
    Structure-based drug design of small molecule peptide deformylase inhibitors to treat cancer (2016), Molecules, 21, 396 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.88

Application

Application Comment Organism
drug development human peptide deformylase (HsPDF) is an important target for anticancer drug discovery Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(2-ethoxy-4-(((4-(3-oxomorpholino)phenyl)amino)methyl)phenoxy)-N-hydroxyacetamide the compound exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 0.0364, 0.120, and 0.0480 mM, respectively Homo sapiens
2-(2-ethoxy-4-((morpholinoamino)methyl)phenoxy)-N-hydroxyacetamide the compound exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 0.0096, 0.0679, and 0.0229 mM, respectively Homo sapiens
2-(2-ethoxy-4-((pyridin-3-ylamino)methyl)phenoxy)-N-hydroxyacetamide the compound exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 0.0966, 0.0454, and 0.0136 mM, respectively Homo sapiens
2-[2-chloro-4-([[2-(1H-indol-3-yl)ethyl]amino]methyl)-6-methoxyphenoxy]acetamide i.e. M7594_0037, the compound exhibits potent anticancer activities against HeLa, A549 and MCF-7 cell lines with IC50s of 0.0353, 0.0296, and 0.0246 mM, respectively Homo sapiens
actinonin
-
 Homo sapiens
ethyl 2-(2-ethoxy-4-(((4-(3-oxomorpholino)phenyl)amino)methyl)phenoxy)acetate
-
 Homo sapiens
ethyl 2-(2-ethoxy-4-((morpholinoamino)methyl)phenoxy)acetate
-
 Homo sapiens
ethyl 2-(2-ethoxy-4-formylphenoxy)acetate
-
 Homo sapiens
additional information structure-based drug design of small molecule peptide deformylase inhibitors to treat cancer, molecular docking studies revealing that M7594_0037 and its three derivatives interact with HsPDF by several conserved hydrogen bonds. Compound synthesis using the crystal structure of the HsPDF complex with actinonin (PDB ID 3G5K) as template Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBH1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
HsPDF
-
 Homo sapiens
PDF
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 in vivo assay at Homo sapiens