Literature summary for 3.5.1.88 extracted from

Liang, L.; Zhou, Q.; Hao, Z.; Wang, F.; Zhu, Y.; Lin, Q.; Gao, J.
The discovery of antibacterial natural compound based on peptide deformylase (2018), Comb. Chem. High Throughput Screen., 21, 292-297 .

Search for more literature for 3.5.1.88

Application

Application	Comment	Organism
drug development	peptide deformylase (PDF), a metalloprotease, is an important antibacterial drug target	Staphylococcus aureus

Inhibitors

Inhibitors	Comment	Organism	Structure
cryptochlorogenic acid	with high score in enzyme docking analysis	Staphylococcus aureus
dihydromyricetin	with high score in enzyme docking analysis	Staphylococcus aureus
gentiopicroside	with high score in enzyme docking analysis	Staphylococcus aureus
additional information	PDF-based virtual screening of compounds from Traditional Chinese Medicine (TCM) and discovery of antibacterial natural compounds via inhibition of peptide deformylase, MIC values, overview	Staphylococcus aureus
protosappanin B	with high score in enzyme docking analysis	Staphylococcus aureus

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	metalloprotease	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Staphylococcus aureus	P68826	-	-

Synonyms

Synonyms	Comment	Organism
PDF	-	Staphylococcus aureus

General Information

General Information	Comment	Organism
physiological function	peptide deformylase (PDF) catalyzes the removal of a formyl group from newly synthesized proteins	Staphylococcus aureus

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Release 2023.1 (January 2023)