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Literature summary for 3.5.1.88 extracted from
- Bacterial peptide deformylase inhibition of cyano substituted biaryl analogs synthesis, in vitro biological evaluation, molecular docking study and in silico ADME prediction (2016), Bioorg. Med. Chem., 24, 3456-3463 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4'-((2-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli |  |
| 4'-((2-nitrophenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((3-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((3-fluoro-4-morpholinophenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((3-nitrophenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((4-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((4-carboxyphenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((4-chloro-2-nitrophenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((4-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((4H-1,2,4-triazol-4-ylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((6-methoxybenzothiazol-2-ylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((phenylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| 4'-((pyrazin-2-ylamino)methyl)biphenyl-2-carbonitrile | - |
Escherichia coli | |
| additional information | cacterial peptide deformylase inhibition of cyano-substituted biaryl analogues, synthesis, in vitro biological evaluation, molecular docking study, and in silico ADME (absorption, distribution, metabolism, excretion) prediction, overview. Structure-activity studies. In vitro antibacterial activity analysis of the synthesized compounds against Escherichia coli strain NCIM-2256 and Bacillus subtilis strain NCIM-2063 | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | P0A6K3 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-Met-Ala + H2O | - |
Escherichia coli | formate + Met-Ala | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
- |
Escherichia coli |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Escherichia coli |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.01316 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((phenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.01566 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((2-nitrophenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.01916 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((pyrazin-2-ylamino)methyl)biphenyl-2-carbonitrile | |
| 0.02091 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((3-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.025 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((3-nitrophenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.02775 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((6-methoxybenzothiazol-2-ylamino)methyl)biphenyl-2-carbonitrile | |
| 0.02825 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((4-chloro-2-nitrophenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.033 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((2-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.0335 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((4-(trifluoromethyl)phenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.03458 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((4-hydroxyphenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.0425 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((3-fluoro-4-morpholinophenylamino)methyl)biphenyl-2-carbonitrile | |
| 0.05075 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((4H-1,2,4-triazol-4-ylamino)methyl)biphenyl-2-carbonitrile | |
| 0.05116 | - |
pH 7.4, 30°C, recombinant enzyme | Escherichia coli | 4'-((4-carboxyphenylamino)methyl)biphenyl-2-carbonitrile | |
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