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Literature summary for 3.5.1.88 extracted from

  • Randhawa, H.; Chikara, S.; Gehring, D.; Yildirim, T.; Menon, J.; Reindl, K.M.
    Overexpression of peptide deformylase in breast, colon, and lung cancers (2013), BMC Cancer, 13, 321.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.88

Inhibitors

Inhibitors Comment Organism Structure
actinonin enzyme inhibitor, inhibits the growth of both cancer and non-cancer cell lines Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
20000
-
 x * 20000, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9HBH1
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
breast
-
 Homo sapiens
-
CCD-18Co cell
-
 Homo sapiens
-
colon
-
 Homo sapiens
-
HS578Bst cell
-
 Homo sapiens
-
HS578T cell
-
 Homo sapiens
-
Hs888Lu cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-
additional information expression pattern of the enzyme in cancerous tissues, overview Homo sapiens
-
additional information various types of cancer cell lines from breast, colon, kidney, liver, lung, ovarian, prostate, or thyroid. The enzyme levels are elevated in cancer cell lines compared to non-cancer lines, PDF mRNA levels are significantly increased in breast, colon, and lung cancer samples Homo sapiens
-
ovary
-
 Homo sapiens
-
PC-3 cell
-
 Homo sapiens
-
PrEC cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-
thyroid
-
 Homo sapiens
-

Subunits

Subunits Comment Organism
? x * 20000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
PDF
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens inhibition of the MEK/ERK, but not PI3K or mTOR, pathway reduces the expression of the enzyme in both colon and lung cancer cell lines down

General Information

General Information Comment Organism
malfunction inhibition of the MEK/ERK, but not PI3K or mTOR, pathway reduces the expression of the enzyme in both colon and lung cancer cell lines Homo sapiens
physiological function the MEK/ERK pathway plays a role in regulating the expression of the peptide deformylase in human tissues, overview. The enzyme may act as an oncogene to promote cancer cell proliferation Homo sapiens