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Literature summary for 3.5.1.88 extracted from

  • Pereira-Castro, I.; Costa, L.T.; Amorim, A.; Azevedo, L.
    Transcriptional regulation of the human mitochondrial peptide deformylase (PDF) (2012), Biochem. Biophys. Res. Commun., 421, 825-831.
    View publication on PubMed
Search for more literature for 3.5.1.88

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-formyl-L-methionine polypeptide + H2O Homo sapiens
-
 formate + methionine-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
AGS cell
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-formyl-L-methionine polypeptide + H2O
-
 Homo sapiens formate + methionine-polypeptide
-
 ?

Synonyms

Synonyms Comment Organism
PDF
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens enzyme expression is regulated by members of the Sp family of transcription factors, particularly by Sp1 up

General Information

General Information Comment Organism
metabolism peptide deformylase (PDF) is a protein of the N-terminal methionine excision pathway that removes formylmethionine from mitochondrial-encoded proteins. PDF is crucial in maintaining mitochondrial function Homo sapiens