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Literature summary for 3.5.1.88 extracted from

  • Chae, P.S.; Kim, M.; Jeung, C.; Lee, S.D.; Park, H.; Lee, S.; Suh, J.
    Peptide-cleaving catalyst selective for peptide deformylase (2005), J. Am. Chem. Soc., 127, 2396-2397.
    View publication on PubMed

Application

Application Comment Organism
medicine target of antibiotic drugs Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
Co(III)1 peptide cleaving catalyst Escherichia coli

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Escherichia coli
Zn2+
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Escherichia coli
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Oxidation Stability

Oxidation Stability Organism
active peptide deformylase has an Fe2+ ion in the active site, which reacts readily with oxygen. To obtain a stable variant, Fe ist often substituted with Zn. Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Escherichia coli formate + methionyl peptide
-
?

Synonyms

Synonyms Comment Organism
PDF
-
Escherichia coli
peptide deformylase
-
Escherichia coli