Application | Comment | Organism |
---|---|---|
medicine | peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs | Staphylococcus aureus |
medicine | peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
actinonin | - |
Escherichia coli | |
actinonin | - |
Staphylococcus aureus | |
BB-83698 | - |
Staphylococcus aureus | |
isoxazole-3-hydroxamic acids | 23 different compounds were synthesized and compared to the inhibitory activity of actinonin | Escherichia coli | |
isoxazole-3-hydroxamic acids | 23 different compounds were synthesized and compared to the inhibitory activity of actinonin | Staphylococcus aureus | |
reverse hydroxamate | British Biotech BB-83698 | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-L-methionyl peptide + H2O | Staphylococcus aureus | - |
formate + methionyl peptide | - |
? | |
formyl-L-methionyl peptide + H2O | Escherichia coli | - |
formate + methionyl peptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P0A6K3 | - |
- |
Staphylococcus aureus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
formyl-L-methionyl peptide + H2O | - |
Staphylococcus aureus | formate + methionyl peptide | - |
? | |
formyl-L-methionyl peptide + H2O | - |
Escherichia coli | formate + methionyl peptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
- |
Staphylococcus aureus | |
- |
Escherichia coli | |
peptide deformylase | - |
Staphylococcus aureus |
peptide deformylase | - |
Escherichia coli |