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Literature summary for 3.5.1.88 extracted from

  • Cali, P.; Naerum, L.; Mukhija, S.; Hjelmencrantz, A.
    Isoxazole-3-hydroxamic acid derivatives as peptide deformylase inhibitors and potential antibacterial agents (2004), Bioorg. Med. Chem. Lett., 14, 5997-6000.
    View publication on PubMed

Application

Application Comment Organism
medicine peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs Staphylococcus aureus
medicine peptide deformylase represents a target for the discovery of broad spectrum antibacterial drugs Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
actinonin
-
Escherichia coli
actinonin
-
Staphylococcus aureus
BB-83698
-
Staphylococcus aureus
isoxazole-3-hydroxamic acids 23 different compounds were synthesized and compared to the inhibitory activity of actinonin Escherichia coli
isoxazole-3-hydroxamic acids 23 different compounds were synthesized and compared to the inhibitory activity of actinonin Staphylococcus aureus
reverse hydroxamate British Biotech BB-83698 Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
formyl-L-methionyl peptide + H2O Staphylococcus aureus
-
formate + methionyl peptide
-
?
formyl-L-methionyl peptide + H2O Escherichia coli
-
formate + methionyl peptide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli P0A6K3
-
-
Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
formyl-L-methionyl peptide + H2O
-
Staphylococcus aureus formate + methionyl peptide
-
?
formyl-L-methionyl peptide + H2O
-
Escherichia coli formate + methionyl peptide
-
?

Synonyms

Synonyms Comment Organism
PDF
-
Staphylococcus aureus
PDF
-
Escherichia coli
peptide deformylase
-
Staphylococcus aureus
peptide deformylase
-
Escherichia coli