Literature summary for 3.5.1.81 extracted from

Gao, X.; Ma, Q.; Zhu, H.
Distribution, industrial applications, and enzymatic synthesis of D-amino acids (2015), Appl. Microbiol. Biotechnol., 99, 3341-3349 .

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Application

Application	Comment	Organism
industry	industrial applications of D-amino acids, produced by several different enzymes on different pathways, including the N-acyl-D-amino acid amidohydrolase, are in the pharmaceutical industry for antibiotics production or as medicine, or in food industry for food sweeteners, or in cosmetics in skin protection products	Alcaligenes sp.
synthesis	the D-stereospecific amidohydrolase hydrolyzes the N-acyl-D-amino acid to produce its corresponding D-amino acid, and N-acyl-D-amino acid is left to be used again for chemical racemization. D-amino acids produced by this method include D-Ala, D-Arg, D-Asp, D-Glu, and D-Leu. Commercial process, overview	Alcaligenes sp.

Protein Variants

Protein Variants	Comment	Organism
additional information	optimization of the enzyme for use on large-scale industrial applications	Alcaligenes sp.

Organism

Organism	UniProt	Comment	Textmining
Alcaligenes sp.	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	N-acyl-D-amino acid amidohydrolase catalyzes the hydrolysis of N-acyl-D-amino acid to its corresponding D-amino acid and fatty acid from an amino acid mixture or the N-acyl-DL-amino acid directly	Alcaligenes sp.	?	-	-

Synonyms

Synonyms	Comment	Organism
D-amidohydrolase	-	Alcaligenes sp.
N-Acyl-D-amino acid amidohydrolase	-	Alcaligenes sp.

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Release 2023.1 (January 2023)