Literature summary for 3.5.1.60 extracted from

Zhou, P.; Xiang, L.; Yang, Y.; Wu, Y.; Hu, T.; Liu, X.; Lin, F.; Xiu, Y.; Wu, K.; Lu, C.; Ren, J.; Qiu, Y.; Li, Y.
N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis (2019), Pharmacol. Res., 145, 104264 .

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Application

Application	Comment	Organism
pharmacology	NAAA inhibitor F215 is a therapeutic agent for osteoarthritis. The therapeutic effects of F215 are blocked by the PPAR-alpha antagonist MK886	Homo sapiens
pharmacology	NAAA inhibitor F215 is a therapeutic agent for osteoarthritis. The therapeutic effects of F215 are blocked by the PPAR-alpha antagonist MK886	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one	i.e. F215, the NAAA inhibitor F215 is a therapeutic agent for osteoarthritis	Homo sapiens
3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one	i.e. F215, a NAAA inhibitor	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q02083	-	-
Rattus norvegicus	Q5KTC7	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cartilage	-	Homo sapiens	-
cartilage	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
acylethanolamine acid amidase	-	Homo sapiens
acylethanolamine acid amidase	-	Rattus norvegicus
NAAA	-	Homo sapiens
NAAA	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	prevention against cartilage degeneration by i.p. injection of enzyme inhibitor F215 in osteoarthritis rats	Rattus norvegicus
physiological function	the enzyme is implicated in osteoarthritis progression	Homo sapiens
physiological function	the enzyme is implicated in osteoarthritis progression	Rattus norvegicus

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Release 2023.1 (January 2023)