Cloned (Comment) | Organism |
---|---|
gene Naaa, recombinant expression in HEK-293 cells | Homo sapiens |
gene Naaa, stable transfection and functional recombinant expression in HEK-293 cells | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-cyclohexylbutyl-N-[(R)-2-oxoazetidin-3-yl]carbamate | - |
Homo sapiens | |
4-cyclohexylbutyl-N-[(R)-2-oxoazetidin-3-yl]carbamate | - |
Mus musculus | |
4-cyclohexylbutyl-N-[(R)-2-oxoazetidin-3-yl]carbamate | - |
Rattus norvegicus | |
4-cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate | it blocks enzyme NAAA by covalently binding to the enzyme's catalytic cysteine and displays pronounced antiinflammatory properties in human macrophages | Homo sapiens | |
4-cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate | the compound is quickly eliminated in vivo. It blocks enzyme NAAA by covalently binding to the enzyme's catalytic cysteine and displays pronounced antiinflammatory properties in mouse models | Mus musculus | |
4-cyclohexylbutyl-N-[(S)-2-oxoazetidin-3-yl]carbamate | the compound is quickly eliminated in vivo | Rattus norvegicus | |
5-phenylpentyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate | - |
Homo sapiens | |
5-phenylpentyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate | - |
Mus musculus | |
5-phenylpentyl-N-[(2S,3R)-2-methyl-4-oxo-oxetan-3-yl]carbamate | - |
Rattus norvegicus | |
additional information | inhibitor desing and synthesis of a class of beta-lactam derivatives that are potent, selective, and systemically active inhibitors of intracellular NAAA activity, reaction mechanisms via acylation or alkylation of the enzyme, overview | Homo sapiens | |
additional information | inhibitor desing and synthesis of a class of beta-lactam derivatives that are potent, selective, and systemically active inhibitors of intracellular NAAA activity, reaction mechanisms via acylation or alkylation of the enzyme, overview | Mus musculus | |
additional information | inhibitor desing and synthesis of a class of beta-lactam derivatives that are potent, selective, and systemically active inhibitors of intracellular NAAA activity, reaction mechanisms via acylation or alkylation of the enzyme, overview | Rattus norvegicus | |
N-[(3S)-2-oxoazetidin-3-yl]nonanamide | - |
Homo sapiens | |
N-[(3S)-2-oxoazetidin-3-yl]nonanamide | - |
Mus musculus | |
N-[(3S)-2-oxoazetidin-3-yl]nonanamide | - |
Rattus norvegicus | |
N-[(3S)-2-oxooxetan-3-yl]-3-phenylpropanamide | - |
Homo sapiens | |
N-[(3S)-2-oxooxetan-3-yl]-3-phenylpropanamide | - |
Mus musculus | |
N-[(3S)-2-oxooxetan-3-yl]-3-phenylpropanamide | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Homo sapiens | 5764 | - |
lysosome | - |
Rattus norvegicus | 5764 | - |
lysosome | - |
Mus musculus | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
oleoylethanolamide + H2O | Homo sapiens | - |
oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | Rattus norvegicus | - |
oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | Mus musculus | - |
oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | Mus musculus C57BL/6J | - |
oleate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Homo sapiens | - |
palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Rattus norvegicus | - |
palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Mus musculus | - |
palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | Mus musculus C57BL/6J | - |
palmitate + ethanolamine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02083 | - |
- |
Mus musculus | Q9D7V9 | - |
- |
Mus musculus C57BL/6J | Q9D7V9 | - |
- |
Rattus norvegicus | Q5KTC7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Rattus norvegicus | - |
lung | - |
Mus musculus | - |
macrophage | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
oleoylethanolamide + H2O | - |
Homo sapiens | oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | - |
Rattus norvegicus | oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | - |
Mus musculus | oleate + ethanolamine | - |
? | |
oleoylethanolamide + H2O | - |
Mus musculus C57BL/6J | oleate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Homo sapiens | palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Rattus norvegicus | palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Mus musculus | palmitate + ethanolamine | - |
? | |
palmitoylethanolamide + H2O | - |
Mus musculus C57BL/6J | palmitate + ethanolamine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
N-acylethanolamine acid amidase | - |
Homo sapiens |
N-acylethanolamine acid amidase | - |
Rattus norvegicus |
N-acylethanolamine acid amidase | - |
Mus musculus |
NAAA | - |
Homo sapiens |
NAAA | - |
Rattus norvegicus |
NAAA | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Rattus norvegicus |
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
8 | - |
assay at | Rattus norvegicus |
8 | - |
assay at | Mus musculus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetic analysis | Homo sapiens |