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Literature summary for 3.5.1.60 extracted from

  • Li, Y.; Yang, L.; Chen, L.; Zhu, C.; Huang, R.; Zheng, X.; Qiu, Y.; Fu, J.
    Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds (2012), PLoS ONE, 7, e43023.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.60

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of the enzyme in HEK-293 cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
([1,1'-biphenyl]-4-yl)methyl cyclopentanecarboxylate
-
 Rattus norvegicus
1-(2-(4-benzyloxy)phenyl)ethyl-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(2-biphenyl-4-yl)ethyl-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(2-naphthalenyl)acetyl pyrrolidine
-
 Rattus norvegicus
1-(2-naphthalenyl)carbonyl pyrrolidine
-
 Rattus norvegicus
1-(2-phenylethyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(3-phenylpropanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(4-benzyloxy)benzyl-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(4-phenylbenzyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(4-phenylbutanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(5-phenylpentanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(6-phenylhexanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(7-phenylheptanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
1-(biphenyl-4-ylcarbonyl)pyrrolidine
-
 Rattus norvegicus
1-benzyl-carbonyl pyrrolidine
-
 Rattus norvegicus
1-pentadecanyl-carbonyl piperidine
-
 Rattus norvegicus
1-pentadecanyl-carbonyl pyrrole
-
 Rattus norvegicus
1-pentadecanyl-carbonyl pyrrolidine
-
 Rattus norvegicus
1-[3-([1,1'-biphenyl]-4-yl)propyl]pyrrolidine
-
 Rattus norvegicus
biphenyl-4-ylmethyl pyrrolidinyl-1-carboxylate
-
 Rattus norvegicus
cyclopentyl palmitate
-
 Rattus norvegicus
additional information design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase inhibitors, derivatives of 1-pentadecanyl-carbonyl pyrrolidine, as anti-inflammatory compounds, computational docking analysis, structure-activity relationship, overview Rattus norvegicus
N-(biphenyl-4-ylmethyl)pyrrolidinyl-1-carboxamide
-
 Rattus norvegicus
N-cyclopentylpalmitamide
-
 Rattus norvegicus
N-[([1,1'-biphenyl]-4-yl)methyl]cyclopentanecarboxamide
-
 Rattus norvegicus
tetrahydrofuran-3-yl palmitate
-
 Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Rattus norvegicus 5764
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q5KTC7
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(10Z)-heptadecenoylethanolamide + H2O
-
 Rattus norvegicus (10Z)-heptadec-10-enoic acid + ethanolamine
-
 ?

Synonyms

Synonyms Comment Organism
N-acylethanolaminehydrolyzing acid amidase
-
 Rattus norvegicus
NAAA
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
 assay at Rattus norvegicus