BRENDA - Enzyme Database show
show all sequences of 3.5.1.6

beta-Ureidopropionase with N-carbamoyl-alpha-L-amino acid amidohydrolase activity from an aerobic bacterium, Pseudomonas putida IFO 12996

Ogawa, J.; Shimizu, S.; Eur. J. Biochem. 223, 625-630 (1994)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
2,2'-dipyridyl
2 mM 70% inhibition
Pseudomonas putida
5,5'-dithiobis-(2-nitrobenzoic acid)
-
Pseudomonas putida
8-hydroxyquinoline
2 mM 100% inhibition
Pseudomonas putida
Ag+
-
Pseudomonas putida
beta-Alanine
product inhibition
Pseudomonas putida
beta-Alanine
product inhibition
Rattus rattus
Cd2+
-
Pseudomonas putida
Cu2+
-
Euglena gracilis
Cu2+
-
Pseudomonas putida
ethylendiaminetetraacetate
2 mM 100% inhibition
Pseudomonas putida
Hg2+
-
Pseudomonas putida
N-carbamoyl-D-alanine
-
Pseudomonas putida
N-carbamoyl-L-leucine
-
Pseudomonas putida
N-ethylmaleimide
-
Pseudomonas putida
o-phenanthroline
2 mM 93% inhibition
Pseudomonas putida
p-chloromercuribenzoic acid
-
Pseudomonas putida
Pb2+
-
Pseudomonas putida
phenylhydrazine
49% inhibition
Pseudomonas putida
Semicarbazide
78% inhibition
Pseudomonas putida
Sn2+
-
Pseudomonas putida
sodium propionate
-
Pseudomonas putida
sodium propionate
-
Rattus rattus
Zn2+
-
Pseudomonas putida
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.68
-
N-Carbamoylglycine
-
Pseudomonas putida
1.56
-
N-Carbamoyl-beta-alanine
-
Pseudomonas putida
2.81
-
N-carbamoyl-beta-aminoisobutyric acid
-
Pseudomonas putida
3.74
-
beta-ureidopropionic acid
-
Pseudomonas putida
4.52
-
DL-beta-ureidobutyric acid
-
Pseudomonas putida
7.71
-
N-formyl-DL-alanine
-
Pseudomonas putida
8.78
-
N-acetyl-DL-alanine
-
Pseudomonas putida
11.6
-
gamma-ureido-n-butyrate
-
Pseudomonas putida
42.3
-
N-carbamoyl-DL-2-aminovaleric acid
-
Pseudomonas putida
75.1
-
N-carbamoyl-L-serine
-
Pseudomonas putida
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Pseudomonas putida
5829
-
cytosol
-
Rattus rattus
5829
-
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Euglena gracilis
Mg2+
-
Pseudomonas putida
Ni2+
-
Pseudomonas putida
Zn2+
-
Pseudomonas putida
Zn2+
-
Rattus rattus
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
6 * 42000, SDS-PAGE
Rattus rattus
45000
-
2 * 45000, SDS-PAGE
Pseudomonas putida
95000
-
gel filtration
Pseudomonas putida
240000
-
gel filtration
Rattus rattus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-carbamoyl-beta-alanine + H2O
Mus musculus
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Euglena gracilis
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Pseudomonas putida
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Comamonas sp.
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Rattus rattus
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Clostridium uracilicum
-
?
-
-
-
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Clostridium uracilicum
-
-
-
Comamonas sp.
-
-
-
Euglena gracilis
-
plant-like unicellular flagellate
-
Mus musculus
-
-
-
Pseudomonas putida
-
IFO 12996
-
Rattus rattus
-
-
-
Purification (Commentary)
Commentary
Organism
-
Pseudomonas putida
Source Tissue
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
liver
-
Rattus rattus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-beta-ureidobutyric acid + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
gamma-ureido-n-butyric acid + H2O
-
172065
Pseudomonas putida
4-aminobutanoate + CO2 + NH3
-
-
-
?
N-acetyl-DL-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
N-carbamoyl-beta-alanine + H2O
-
172065
Comamonas sp.
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Mus musculus
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Euglena gracilis
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Pseudomonas putida
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Rattus rattus
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Clostridium uracilicum
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
-
172065
Mus musculus
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Euglena gracilis
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Comamonas sp.
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Rattus rattus
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Clostridium uracilicum
?
-
-
-
-
N-carbamoyl-DL-2-aminovaleric acid + H2O
-
172065
Pseudomonas putida
2-aminopentanoate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Euglena gracilis
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Pseudomonas putida
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Rattus rattus
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-L-serine + H2O
-
172065
Pseudomonas putida
L-serine + CO2 + NH3
-
-
-
?
N-carbamoylglycine + H2O
-
172065
Pseudomonas putida
glycine + CO2 + NH3
-
-
-
?
N-carbamoylglycine + H2O
-
172065
Rattus rattus
glycine + CO2 + NH3
-
-
-
?
N-formyl-DL-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 45000, SDS-PAGE
Pseudomonas putida
hexamer
6 * 42000, SDS-PAGE
Rattus rattus
Temperature Optimum [°C]
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Euglena gracilis
60
-
-
Pseudomonas putida
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
65
-
80% activity lost at 70°C
Pseudomonas putida
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.2
-
Pseudomonas putida
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
6.1
10.7
-
Pseudomonas putida
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
2,2'-dipyridyl
2 mM 70% inhibition
Pseudomonas putida
5,5'-dithiobis-(2-nitrobenzoic acid)
-
Pseudomonas putida
8-hydroxyquinoline
2 mM 100% inhibition
Pseudomonas putida
Ag+
-
Pseudomonas putida
beta-Alanine
product inhibition
Pseudomonas putida
beta-Alanine
product inhibition
Rattus rattus
Cd2+
-
Pseudomonas putida
Cu2+
-
Euglena gracilis
Cu2+
-
Pseudomonas putida
ethylendiaminetetraacetate
2 mM 100% inhibition
Pseudomonas putida
Hg2+
-
Pseudomonas putida
N-carbamoyl-D-alanine
-
Pseudomonas putida
N-carbamoyl-L-leucine
-
Pseudomonas putida
N-ethylmaleimide
-
Pseudomonas putida
o-phenanthroline
2 mM 93% inhibition
Pseudomonas putida
p-chloromercuribenzoic acid
-
Pseudomonas putida
Pb2+
-
Pseudomonas putida
phenylhydrazine
49% inhibition
Pseudomonas putida
Semicarbazide
78% inhibition
Pseudomonas putida
Sn2+
-
Pseudomonas putida
sodium propionate
-
Pseudomonas putida
sodium propionate
-
Rattus rattus
Zn2+
-
Pseudomonas putida
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.68
-
N-Carbamoylglycine
-
Pseudomonas putida
1.56
-
N-Carbamoyl-beta-alanine
-
Pseudomonas putida
2.81
-
N-carbamoyl-beta-aminoisobutyric acid
-
Pseudomonas putida
3.74
-
beta-ureidopropionic acid
-
Pseudomonas putida
4.52
-
DL-beta-ureidobutyric acid
-
Pseudomonas putida
7.71
-
N-formyl-DL-alanine
-
Pseudomonas putida
8.78
-
N-acetyl-DL-alanine
-
Pseudomonas putida
11.6
-
gamma-ureido-n-butyrate
-
Pseudomonas putida
42.3
-
N-carbamoyl-DL-2-aminovaleric acid
-
Pseudomonas putida
75.1
-
N-carbamoyl-L-serine
-
Pseudomonas putida
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytosol
-
Pseudomonas putida
5829
-
cytosol
-
Rattus rattus
5829
-
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
-
Euglena gracilis
Mg2+
-
Pseudomonas putida
Ni2+
-
Pseudomonas putida
Zn2+
-
Pseudomonas putida
Zn2+
-
Rattus rattus
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
42000
-
6 * 42000, SDS-PAGE
Rattus rattus
45000
-
2 * 45000, SDS-PAGE
Pseudomonas putida
95000
-
gel filtration
Pseudomonas putida
240000
-
gel filtration
Rattus rattus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
N-carbamoyl-beta-alanine + H2O
Mus musculus
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Euglena gracilis
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Pseudomonas putida
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Comamonas sp.
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Rattus rattus
-
?
-
-
-
N-carbamoyl-beta-alanine + H2O
Clostridium uracilicum
-
?
-
-
-
Purification (Commentary) (protein specific)
Commentary
Organism
-
Pseudomonas putida
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
liver
-
Mus musculus
-
liver
-
Rattus rattus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
DL-beta-ureidobutyric acid + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
gamma-ureido-n-butyric acid + H2O
-
172065
Pseudomonas putida
4-aminobutanoate + CO2 + NH3
-
-
-
?
N-acetyl-DL-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
N-carbamoyl-beta-alanine + H2O
-
172065
Comamonas sp.
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Mus musculus
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Euglena gracilis
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Pseudomonas putida
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Rattus rattus
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
L enantiomer specific hydrolysis
172065
Clostridium uracilicum
beta-alanine + CO2 + NH3
-
-
-
ir
N-carbamoyl-beta-alanine + H2O
-
172065
Mus musculus
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Euglena gracilis
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Comamonas sp.
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Rattus rattus
?
-
-
-
-
N-carbamoyl-beta-alanine + H2O
-
172065
Clostridium uracilicum
?
-
-
-
-
N-carbamoyl-DL-2-aminovaleric acid + H2O
-
172065
Pseudomonas putida
2-aminopentanoate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Euglena gracilis
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Pseudomonas putida
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-DL-beta-aminoisobutyrate + H2O
-
172065
Rattus rattus
DL-beta-aminoisobutyrate + CO2 + NH3
-
-
-
?
N-carbamoyl-L-serine + H2O
-
172065
Pseudomonas putida
L-serine + CO2 + NH3
-
-
-
?
N-carbamoylglycine + H2O
-
172065
Pseudomonas putida
glycine + CO2 + NH3
-
-
-
?
N-carbamoylglycine + H2O
-
172065
Rattus rattus
glycine + CO2 + NH3
-
-
-
?
N-formyl-DL-alanine + H2O
-
172065
Pseudomonas putida
?
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 45000, SDS-PAGE
Pseudomonas putida
hexamer
6 * 42000, SDS-PAGE
Rattus rattus
Temperature Optimum [°C] (protein specific)
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
60
-
-
Euglena gracilis
60
-
-
Pseudomonas putida
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
65
-
80% activity lost at 70°C
Pseudomonas putida
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.5
8.2
-
Pseudomonas putida
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
6.1
10.7
-
Pseudomonas putida
Other publictions for EC 3.5.1.6
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
733675
Lam
NMR-based urinalysis for rapid ...
Homo sapiens
Clin. Chim. Acta
440
201-204
2015
-
-
1
-
1
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2
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1
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1
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1
1
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734810
Meijer
Publishers note. Identificatio ...
Homo sapiens
Nucleosides Nucleotides Nucleic Acids
33
639-645
2014
-
-
1
-
3
-
-
-
-
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2
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1
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2
-
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2
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1
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3
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2
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2
-
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2
-
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-
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-
-
-
-
-
-
1
1
-
-
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734855
Shen
Expression of a gene encoding ...
Solanum lycopersicum, Solanum lycopersicum CL5915, Solanum lycopersicum L4783
Physiol. Plant.
150
425-435
2014
-
-
1
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1
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4
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1
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1
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1
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1
-
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-
-
-
-
-
-
-
-
-
-
-
1
1
-
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-
733382
Van Kuilenburg
beta-Ureidopropionase deficien ...
Homo sapiens
Biochim. Biophys. Acta
1822
1096-1108
2012
-
-
1
-
6
-
-
-
-
-
1
2
-
1
-
-
1
-
-
-
3
-
2
1
-
-
-
-
-
-
-
-
-
-
-
-
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1
-
-
6
-
-
-
-
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1
2
-
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-
1
-
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3
-
2
1
-
-
-
-
-
-
-
-
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3
3
-
-
-
734844
Fidlerova
Contribution of the beta-ureid ...
Homo sapiens
Pharmacol. Rep.
64
1234-1242
2012
-
-
1
-
-
-
-
-
-
-
-
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-
1
-
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-
-
-
-
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1
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Matthews
Regulation of N-carbamoyl-beta ...
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Traut
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Kaspari
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Wasternack
Pyrimidine-degrading enzymes p ...
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1
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4
1
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12
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1
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1
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172062
Campbell
Reductive degradation of pyrim ...
Canis lupus familiaris, Clostridium uracilicum, Clostridium uracilicum M5-2, Oryctolagus cuniculus, Pigeon, Rattus rattus
J. Biol. Chem.
235
2375-2379
1960
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1
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6
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9
-
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1
-
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4
-
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12
-
1
1
1
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2
1
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1
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6
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1
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4
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12
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1
1
1
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2
1
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172063
Caravaca
Enzymatic decarbamylation of c ...
Canis lupus familiaris, Oryctolagus cuniculus, Pigeon, Rattus rattus
J. Biol. Chem.
231
357-365
1958
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2
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4
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4
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4
4
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4
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