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Literature summary for 3.5.1.52 extracted from

  • Masahara-Negishi, Y.; Hosomi, A.; Della Mea, M.; Serafini-Fracassini, D.; Suzuki, T.
    A plant peptide:N-glycanase orthologue facilitates glycoprotein ER-associated degradation in yeast (2012), Biochim. Biophys. Acta, 1810, 1457-1462.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae Arabidopsis thaliana

Protein Variants

Protein Variants Comment Organism
C251A the mutant exhibits a defect in degrading RTADELTA-transmembrane-Leu2 protein. Expression of the catalytic mutant results in significant stabilization of RTADELTA protein by binding to N-glycans on the substrate Arabidopsis thaliana

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Arabidopsis thaliana 5737
-

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information PNG1 can function not only as peptide:N-glycanase but also as transglutaminase Arabidopsis thaliana ?
-
?
RTADELTA protein + H2O RTADELTA is a non-toxic mutant of ricin A-chain Arabidopsis thaliana deglycosylated RTADELTA protein + ?
-
?
RTADELTA-transmembrane-Leu2 protein + H2O
-
Arabidopsis thaliana deglycosylated RTADELTA-transmembrane-Leu2 protein + ?
-
?

Synonyms

Synonyms Comment Organism
peptide:N-glycanase
-
Arabidopsis thaliana
PNG1
-
Arabidopsis thaliana
PNGase
-
Arabidopsis thaliana

General Information

General Information Comment Organism
physiological function the enzyme is a deglycosylating enzyme involved in the endoplasmic reticulum-associated degradation process Arabidopsis thaliana