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Literature summary for 3.5.1.5 extracted from

  • Pan, L.; Wang, C.; Yan, K.; Zhao, K.; Sheng, G.; Zhu, H.; Zhao, X.; Qu, D.; Niu, F.; You, Z.
    Synthesis, structures and Helicobacter pylori urease inhibitory activity of copper(II) complexes with tridentate aroylhydrazone ligands (2016), J. Inorg. Biochem., 159, 22-28 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
copper(II) complex [CuClL1]*CH3OH L2 is the deprotonated form of 4-bromo-N'-(2-hydroxy-5-methoxybenzylidene)benzohydrazide Helicobacter pylori
copper(II) complex [CuClL2]*CH3OH L3 is the deprotonated form of N'-(2-hydroxy-5-methoxybenzylidene)-3-methylbenzohydrazide Helicobacter pylori
copper(II) complex [CuL1(NCS)] L1 is the deprotonated form of N'-(2-hydroxybenzylidene)-3-methylbenzohydrazide. NCS is N-chlorsuccinimide Helicobacter pylori
copper(II) complex [CuL3(NCS)]*CH3OH L4 is the deprotonated form of 2-chloro-N'-(2-hydroxy-5-methoxybenzylidene)benzohydrazide Helicobacter pylori
copper(II) complex [CuL4(NCS)]*0.4H2O L5 is the dianionic form of N'-(2-hydroxybenzylidene)-3-methylbenzohydrazide Helicobacter pylori
copper(II) complex [CuL5(bipy)] bipy is 2,2'-bipyridine Helicobacter pylori

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
urea + H2O Helicobacter pylori
-
CO2 + 2 NH3
-
?
urea + H2O Helicobacter pylori ATCC 43504
-
CO2 + 2 NH3
-
?

Organism

Organism UniProt Comment Textmining
Helicobacter pylori
-
-
-
Helicobacter pylori ATCC 43504
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
urea + H2O
-
Helicobacter pylori CO2 + 2 NH3
-
?
urea + H2O
-
Helicobacter pylori ATCC 43504 CO2 + 2 NH3
-
?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.1
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuL5(bipy)]
0.2
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuClL1]*CH3OH
0.26
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuL4(NCS)]*0.4H2O
4.06
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuClL2]*CH3OH
5.14
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuL1(NCS)]
5.52
-
pH 7.4, 37°C Helicobacter pylori copper(II) complex [CuL3(NCS)]*CH3OH