Application | Comment | Organism |
---|---|---|
medicine | importance of overall cryptococcal urease inhibition, rather than of its enzymatic activity alone, for the future development of therapeutic tools targeting cryptococcosis | Cryptococcus gattii VGI |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ni2+ | Ni2+-dependent metalloenzyme | Cryptococcus gattii VGI |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | Cryptococcus gattii VGI | - |
CO2 + 2 NH3 | - |
? | |
urea + H2O | Cryptococcus gattii VGI R265 | - |
CO2 + 2 NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cryptococcus gattii VGI | Q2QEI4 | hypervirulent strain R265, serotype B, mating type alpha | - |
Cryptococcus gattii VGI R265 | Q2QEI4 | hypervirulent strain R265, serotype B, mating type alpha | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
urea + H2O | - |
Cryptococcus gattii VGI | CO2 + 2 NH3 | - |
? | |
urea + H2O | - |
Cryptococcus gattii VGI R265 | CO2 + 2 NH3 | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | Cryptococcus gattii urease plays an important role in virulence, in part possibly through enzyme activity-independent mechanism(s) | Cryptococcus gattii VGI |