Literature summary for 3.5.1.5 extracted from

Amtul, Z.; Follmer, C.; Mahboob, S.; Atta-Ur-Rahman, S.; Mazhar, M.; Khan, K.M.; Siddiqui, R.A.; Muhammad, S.; Kazmi, S.A.; Choudhary, M.I.
Germa-gamma-lactones as novel inhibitors of bacterial urease activity (2007), Biochem. Biophys. Res. Commun., 356, 457-463.

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Inhibitors

Inhibitors	Comment	Organism	Structure
beta-(o-methoxyphenyl)-gamma,gamma-bis(8-quinolinoxy)germa-gamma-lactone	inhibition occurrs in a noncompetitive and concentration-dependent manner. Highly selective in inhibiting the growth of Proteus mirabilis at moderate concentrations. Potential to be developed as antimicrobial agents against Proteus mirabilis infection	Proteus mirabilis
beta-(o-methylphenyl)-gamma,gamma-bis(8-quinolinoxy)germa-gamma-lactone	inhibition occurrs in a noncompetitive and concentration-dependent manner. Highly selective in inhibiting the growth of Proteus mirabilis at moderate concentrations. Potential to be developed as antimicrobial agents against Proteus mirabilis infection	Proteus mirabilis

Organism

Organism	UniProt	Comment	Textmining
Proteus mirabilis	-	-	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.031	-	-	Proteus mirabilis	beta-(o-methoxyphenyl)-gamma,gamma-bis(8-quinolinoxy)germa-gamma-lactone

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Release 2023.1 (January 2023)