Literature summary for 3.5.1.4 extracted from

Kaczocha, M.; Hermann, A.; Glaser, S.T.; Bojesen, I.N.; Deutsch, D.G.
Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase (2006), J. Biol. Chem., 281, 9066-9075.

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Inhibitors

Inhibitors	Comment	Organism	Structure
CAY10400	-	Rattus norvegicus
OMDM2	0.01 mM, 16% inhibition	Rattus norvegicus
UCM707	-	Rattus norvegicus
URB597	-	Rattus norvegicus
VDM11	-	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
anandamide + H2O	Rattus norvegicus	-	arachidonic acid + ethanolamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RBL-2H3 cell	basophilic leukemia cell. Anandamide uptake is consistent with rate-limited diffusion and is regulated by the degree of its hydrolysis by fatty acid amide hydrolase	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
anandamide + H2O	-	Rattus norvegicus	arachidonic acid + ethanolamine	-	?

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0000005	-	-	Rattus norvegicus	CAY10400
0.000002	-	-	Rattus norvegicus	URB597
0.005	-	-	Rattus norvegicus	VDM11
0.05	-	-	Rattus norvegicus	UCM707

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Release 2023.1 (January 2023)