Literature summary for 3.5.1.4 extracted from

Vandevoorde, S.; Saha, B.; Mahadevan, A.; Razdan, R.K.; Pertwee, R.G.; Martin, B.R.; Fowler, C.J.
Influence of the degree of unsaturation of the acyl side chain upon the interaction of analogues of 1-arachidonoylglycerol with monoacylglycerol lipase and fatty acid amide hydrolase (2005), Biochem. Biophys. Res. Commun., 337, 104-109.

Search for more literature for 3.5.1.4

Inhibitors

Inhibitors	Comment	Organism	Structure
1-arachidin	10% inhibition at 0.1 mM	Rattus norvegicus
1-arachidonoylglycerol	IC50: 0.0062 mM	Rattus norvegicus
1-myristin	IC50: 0.018, complete inhibition is possible	Rattus norvegicus
1-palmitin	IC50: 0.0080, complete inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (11Z)-icos-11-enoate	i.e. O-4066, IC50: 0.010, complete inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate	i.e. O-3907, IC50: 0.0057, complete inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (4Z,7Z,10Z,13Z)-17-ethylcycloheptadeca-4,7,10,13-tetraene-1-carboxylate	i.e. O-1428, 28% inhibition at 0.1 mM	Rattus norvegicus
2,3-dihydroxypropyl (5Z)-icos-5-enoate	i.e. 3908, IC50: 0.011, 84% inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate	i.e. O-3973, IC50: 0.0024, 95% inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate	i.e. O-3832, IC50: 0.0076, complete inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate	i.e. O-4081, IC50: 0.0051, 90% inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate	i.e. O-3872, IC50: 0.014, complete inhibition is possible	Rattus norvegicus
2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate	i.e. 3846, IC50: 0.023, complete inhibition is possible	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
anandamide + H2O	i.e. arachidonoylethanolamide	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
FAAH	-	Rattus norvegicus
fatty acid amide hydrolase	-	Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Rattus norvegicus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.2	-	assay at	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0024	-	i.e. O-3973, IC50: 0.0024, 95% inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (5Z,8Z,11Z)-2-ethylcycloheptadeca-5,8,11-triene-1-carboxylate
0.0051	-	i.e. O-4081, IC50: 0.0051 mM, 90% inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (6Z,9Z,12Z,15Z)-cyclohenicosa-6,9,12,15-tetraene-1-carboxylate
0.0057	-	i.e. O-3907, IC50: 0.0057 mM, complete inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (11Z,14Z)-icosa-11,14-dienoate
0.0062	-	IC50: 0.0062 mM	Rattus norvegicus	1-arachidonoylglycerol
0.0076	-	i.e. O-3832, IC50: 0.0076 mM, complete inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoate
0.008	-	IC50: 0.0080 mM, complete inhibition is possible	Rattus norvegicus	1-palmitin
0.01	-	i.e. O-4066, IC50: 0.010 mM, complete inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (11Z)-icos-11-enoate
0.011	-	i.e. O-3908, IC50: 0.011 mM, 84% inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (5Z)-icos-5-enoate
0.014	-	i.e. O-3872, IC50: 0.014, complete inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (7Z,10Z,13Z,16Z)-docosa-7,10,13,16-tetraenoate
0.018	-	IC50: 0.018 mM, complete inhibition is possible	Rattus norvegicus	1-myristin
0.023	-	i.e. 3846, IC50: 0.023, complete inhibition is possible	Rattus norvegicus	2,3-dihydroxypropyl (8Z,11Z,14Z)-icosa-8,11,14-trienoate

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Release 2023.1 (January 2023)