Literature summary for 3.5.1.4 extracted from

Maestracci, M.; Bui, K.; Thiery, A.; Arnaud, A.; Galzy, P.
A study of the inhibition of an amidase with a wide substrate spectrum and its consequences for the bioconversation of nitriles (1984), Biotechnol. Lett., 6, 149-154.

No PubMed abstract available

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Application

Application	Comment	Organism
synthesis	producing particular organic acids from nitriles and detoxifying waste waters containing nitrile compounds	Brevibacterium sp.

Inhibitors

Inhibitors	Comment	Organism	Structure
acetamide	no inhibition up to 1.0 M concentration in presence of 0.56 mg protein	Brevibacterium sp.
acetic acid	Ki: 240 mM	Brevibacterium sp.
acetonnitrile	Ki: 120 mM	Brevibacterium sp.
acrylonitrile	Ki: 34 mM	Brevibacterium sp.
Methacrylonitrile	Ki: 90 mM	Brevibacterium sp.
Propionitrile	Ki: 280 mM	Brevibacterium sp.

Organism

Organism	UniProt	Comment	Textmining
Brevibacterium sp.	-	mutant strains A4 and 19	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
34	-	acrylonitrile	-	Brevibacterium sp.
90	-	Methacrylonitrile	-	Brevibacterium sp.
120	-	acetonnitrile	-	Brevibacterium sp.
280	-	Propionitrile	-	Brevibacterium sp.

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Release 2023.1 (January 2023)