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Literature summary for 3.5.1.33 extracted from

  • Watterlot, L.; Meyrand, M.; Gaide, N.; Kharrat, P.; Blugeon, S.; Gratadoux, J.J.; Flores, M.J.; Langella, P.; Chapot-Chartier, M.P.; Bermudez-Humaran, L.G.
    Variations of N-acetylation level of peptidoglycan do not influence persistence of Lactococcus lactis in the gastrointestinal tract (2010), Int. J. Food Microbiol., 144, 29-34.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N-acetyl-D-glucosamine + H2O Lactococcus lactis
-
D-glucosamine + acetate
-
?
N-acetyl-D-glucosamine + H2O Lactococcus lactis JIM7049
-
D-glucosamine + acetate
-
?

Organism

Organism UniProt Comment Textmining
Lactococcus lactis
-
-
-
Lactococcus lactis JIM7049
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-D-glucosamine + H2O
-
Lactococcus lactis D-glucosamine + acetate
-
?
N-acetyl-D-glucosamine + H2O
-
Lactococcus lactis JIM7049 D-glucosamine + acetate
-
?

Synonyms

Synonyms Comment Organism
pgdA
-
Lactococcus lactis

General Information

General Information Comment Organism
malfunction inactivation of the N-acetylglucosamine deacetylase gene leads to fully acetylated peptidoglycan, resulting in a lysozyme-sensitive phenotype Lactococcus lactis
physiological function N-acetylglucosamine deacetylase gene overexpression leads to an increased degree of peptidoglycan deacetylation, resulting in a lysozyme-resistant phenotype. N-Acetylglucosamine deacetylase does not confer any advantage in the persistence of Lactococcus lactis in the gastrointestinal tract and its ability to enhance host immune responses induced by delivered antigen in situ Lactococcus lactis