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Literature summary for 3.5.1.31 extracted from
- N-Formyl-methionine deformylase of animal tissues (1977), Biochem. Biophys. Res. Commun., 77, 237-244.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 3.3 | - |
N-formyl-methionine | enzyme from spleen | Rattus norvegicus |  |
| 5 | - |
N-formyl-methionine | enzyme from brain, heart or muscle | Rattus norvegicus | |
| 6.5 | - |
N-formyl-methionine | enzyme from kidney | Rattus norvegicus | |
| 12.5 | - |
N-formyl-methionine | enzyme from liver | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Gallus gallus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| brain | - |
Bos taurus | - |
| heart | - |
Rattus norvegicus | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Gallus gallus | - |
| liver | - |
Rattus norvegicus | - |
| muscle | - |
Rattus norvegicus | - |
| spleen | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-formyl-alanine + H2O | at 2-7% of the activity with N-formyl-methionine, depending on tissue | Rattus norvegicus | formate + alanine | - |
? | |
| N-formyl-L-methionine + H2O | - |
Gallus gallus | formate + L-methionine | - |
? | |
| N-formyl-L-methionine + H2O | - |
Rattus norvegicus | formate + L-methionine | - |
? | |
| N-formyl-L-methionine + H2O | - |
Sus scrofa | formate + L-methionine | - |
? | |
| N-formyl-L-methionine + H2O | - |
Bos taurus | formate + L-methionine | - |
? | |
| N-formyl-leucine + H2O | at 0.8-12% of the activity with N-formyl-methionine, depending on tissue | Rattus norvegicus | formate + leucine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
27% more active with phosphate than with Tris-Cl- buffer | Rattus norvegicus |
| 7.4 | - |
- |
Gallus gallus |
| 7.4 | - |
- |
Rattus norvegicus |
| 7.4 | - |
- |
Sus scrofa |
| 7.4 | - |
- |
Bos taurus |
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Release 2023.1 (January 2023)
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