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Literature summary for 3.5.1.31 extracted from

  • Ackerman, S.K.; Douglas, S.D.
    N-Formyl-L-methionine deformylase activity in human leucocytes and platelets (1979), Biochem. J., 182, 885-887.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline 2 mM, 90-100% inhibition Homo sapiens
dithiothreitol 2 mM, 90-100% inhibition Homo sapiens
EDTA 2 mM, 65-80% inhibition Homo sapiens
phenylmethanesulfonyl fluoride 2 mM, 10% inhibition Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Metals/Ions

Metals/Ions Comment Organism Structure
Co2+ 0.1 mM, 7-10fold stimulation Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
leukocyte
-
Homo sapiens
-
platelet
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme may be important in modulation of neutrophil responses to chemoattractant formylmethionyl peptides or similar compounds Homo sapiens ?
-
?
N-formyl-L-methionine + H2O
-
Homo sapiens formate + L-methionine
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
activity in 0.1 M Tris buffer is 10fold lower than in 0.1 M phosphate buffer, pH 8.5 Homo sapiens
7.5
-
-
Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.5 9.5 pH 6.5: about 75% of maximal activity, pH 9.5: about 50% of maximal activity Homo sapiens