BRENDA - Enzyme Database
show all sequences of 3.5.1.3

The glutamine transaminase-omega-amidase pathway

Cooper, A.J.L.; Meister, A.; CRC Crit. Rev. Biochem. 4, 281-303 (1977) View publication on PubMed

Data extracted from this reference:

Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
most of omega-amidase activity is present in cytoplasm
Rattus norvegicus
5737
-
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58000
-
liver, high-speed sedimentation equilibrium and amino-acid analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2-oxoglutaramate + H2O
Mus musculus
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Mus musculus
?
2-oxoglutaramate + H2O
Homo sapiens
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Homo sapiens
?
2-oxoglutaramate + H2O
Rattus norvegicus
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Rattus norvegicus
?
2-oxoglutaramate + H2O
Saccharomyces cerevisiae
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Saccharomyces cerevisiae
?
2-oxoglutaramate + H2O
Embryophyta
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Embryophyta
?
additional information
Homo sapiens
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
?
-
-
?
additional information
Rattus norvegicus
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
?
-
-
?
additional information
Mus musculus
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Homo sapiens
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Rattus norvegicus
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Rattus norvegicus
glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids
?
-
-
?
Organism
Organism
UniProt
Commentary
Textmining
Canis lupus familiaris
-
-
-
Embryophyta
-
higher plants
-
Enterococcus faecalis
-
-
-
Escherichia coli
-
-
-
Homo sapiens
-
human
-
Lactuca sativa
-
lettuce
-
Mus musculus
-
-
-
Rattus norvegicus
-
contains isozymic forms, mitochondrial and cytosolic, of omega-amidase
-
Rattus norvegicus
-
liver, contains isozymic forms, mitochondrial and cytosolic, of omega-amidase
-
Saccharomyces cerevisiae
-
-
-
Spinacia oleracea
-
spinach
-
Purification (Commentary)
Purification (Commentary)
Organism
liver, cytoplasm
Rattus norvegicus
Reaction
Reaction
Commentary
Organism
Reaction ID
a monoamide of a dicarboxylate + H2O = a dicarboxylate + NH3
mechanism
Rattus norvegicus
Source Tissue
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebrospinal fluid
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Canis lupus familiaris
-
leaf
-
Spinacia oleracea
-
leaf
-
Lactuca sativa
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
additional information
-
Mus musculus
-
additional information
-
Homo sapiens
-
additional information
omega-amidase is widespread, detected in various rat organs
Rattus norvegicus
-
muscle
cardiac muscle and skeletal muscle
Rattus norvegicus
-
Novikoff hepatoma cell
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
2-oxoglutaramate + H2O
sole substrate is the open-chain form of alpha-ketoglutaramate, not the cyclic form
288893
Rattus norvegicus
2-oxoglutarate + NH3
-
288893
Rattus norvegicus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Mus musculus
2-oxoglutarate + NH3
-
288893
Mus musculus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Escherichia coli
2-oxoglutarate + NH3
-
288893
Escherichia coli
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Homo sapiens
2-oxoglutarate + NH3
-
288893
Homo sapiens
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Rattus norvegicus
2-oxoglutarate + NH3
-
288893
Rattus norvegicus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Saccharomyces cerevisiae
2-oxoglutarate + NH3
-
288893
Saccharomyces cerevisiae
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Spinacia oleracea
2-oxoglutarate + NH3
-
288893
Spinacia oleracea
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Canis lupus familiaris
2-oxoglutarate + NH3
-
-
-
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Enterococcus faecalis
2-oxoglutarate + NH3
-
288893
Enterococcus faecalis
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Embryophyta
2-oxoglutarate + NH3
-
288893
Embryophyta
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Lactuca sativa
2-oxoglutarate + NH3
-
288893
Lactuca sativa
?
2-oxosuccinamate + H2O
alpha-ketosuccinamate
288893
Rattus norvegicus
2-oxosuccinate + NH3
-
-
-
?
2-oxosuccinamate + H2O
open-chain form
288893
Rattus norvegicus
2-oxosuccinate + NH3
-
-
-
?
ethyl glutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
ethyl succinate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
gamma-ethyl 2-oxoglutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
gamma-ethyl 2-oxoglutarate + methylamine
gamma-ethyl alpha-ketoglutarate
288893
Rattus norvegicus
?
-
-
-
?
gamma-methyl 2-oxoglutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
glutaramate + H2O
-
288893
Rattus norvegicus
glutarate + NH3
-
-
-
?
glutaramate + hydroxylamine
hydroxaminolysis
288893
Rattus norvegicus
glutaryl hydroxamate + NH3
-
-
-
?
methyl glutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
methyl succinate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
additional information
no hydrolysis of asparagine and glutamine
288893
Rattus norvegicus
?
-
-
-
?
additional information
catalyzes methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
additional information
catalyzes hydroxaminolysis and transamidation reactions with esters and amides
288893
Rattus norvegicus
?
-
-
-
?
additional information
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
288893
Homo sapiens
?
-
-
-
?
additional information
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
288893
Rattus norvegicus
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Mus musculus
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Homo sapiens
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Rattus norvegicus
?
-
-
-
?
additional information
glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids
288893
Rattus norvegicus
?
-
-
-
?
N-methyl-2-oxoglutaramate + H2O
at a slow rate
288893
Rattus norvegicus
2-oxoglutarate + methylamine
-
288893
Rattus norvegicus
?
N-methyl-2-oxoglutaramate + H2O
N-methyl-alpha-ketoglutaramate
288893
Rattus norvegicus
2-oxoglutarate + methylamine
-
288893
Rattus norvegicus
?
succinamate + H2O
-
288893
Rattus norvegicus
succinic acid + NH3
-
-
-
?
succinamate + hydroxylamine
hydroxaminolysis
288893
Rattus norvegicus
succinyl hydroxamate + NH3
-
-
-
r
succinyl hydroxamate + H2O
-
288893
Rattus norvegicus
succinate + hydroxylamine
-
-
-
r
Subunits
Subunits
Commentary
Organism
dimer
liver, 2 * 27000-28000, two subunits may be nonidentical, high-speed sedimentation equilibrium in the presence of 7 M guanidine hydrochloride or 7 M urea containing 0.1 M 2-mercaptoethanol
Rattus norvegicus
Temperature Stability [°C]
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
-
Rattus norvegicus
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
-
Rattus norvegicus
6.5
9.5
broad pH-optimum, hydrolysis of alpha-ketosuccinamate
Rattus norvegicus
9
-
hydrolysis of alpha-ketoglutaramate, sharp maximum
Rattus norvegicus
pH Stability
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
-
Rattus norvegicus
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
cytoplasm
-
Homo sapiens
5737
-
cytoplasm
most of omega-amidase activity is present in cytoplasm
Rattus norvegicus
5737
-
mitochondrion
-
Rattus norvegicus
5739
-
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
58000
-
liver, high-speed sedimentation equilibrium and amino-acid analysis
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
2-oxoglutaramate + H2O
Mus musculus
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Mus musculus
?
2-oxoglutaramate + H2O
Homo sapiens
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Homo sapiens
?
2-oxoglutaramate + H2O
Rattus norvegicus
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Rattus norvegicus
?
2-oxoglutaramate + H2O
Saccharomyces cerevisiae
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Saccharomyces cerevisiae
?
2-oxoglutaramate + H2O
Embryophyta
alpha-ketoglutaramate
2-oxoglutarate + NH3
-
Embryophyta
?
additional information
Homo sapiens
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
?
-
-
?
additional information
Rattus norvegicus
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
?
-
-
?
additional information
Mus musculus
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Homo sapiens
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Rattus norvegicus
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
?
-
-
?
additional information
Rattus norvegicus
glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids
?
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
liver, cytoplasm
Rattus norvegicus
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
brain
-
Mus musculus
-
brain
-
Homo sapiens
-
brain
-
Rattus norvegicus
-
cerebrospinal fluid
-
Homo sapiens
-
heart
-
Rattus norvegicus
-
kidney
-
Homo sapiens
-
kidney
-
Rattus norvegicus
-
kidney
-
Canis lupus familiaris
-
leaf
-
Spinacia oleracea
-
leaf
-
Lactuca sativa
-
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-
additional information
-
Mus musculus
-
additional information
-
Homo sapiens
-
additional information
omega-amidase is widespread, detected in various rat organs
Rattus norvegicus
-
muscle
cardiac muscle and skeletal muscle
Rattus norvegicus
-
Novikoff hepatoma cell
-
Rattus norvegicus
-
pancreas
-
Rattus norvegicus
-
spleen
-
Rattus norvegicus
-
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
2-oxoglutaramate + H2O
sole substrate is the open-chain form of alpha-ketoglutaramate, not the cyclic form
288893
Rattus norvegicus
2-oxoglutarate + NH3
-
288893
Rattus norvegicus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Mus musculus
2-oxoglutarate + NH3
-
288893
Mus musculus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Escherichia coli
2-oxoglutarate + NH3
-
288893
Escherichia coli
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Homo sapiens
2-oxoglutarate + NH3
-
288893
Homo sapiens
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Rattus norvegicus
2-oxoglutarate + NH3
-
288893
Rattus norvegicus
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Saccharomyces cerevisiae
2-oxoglutarate + NH3
-
288893
Saccharomyces cerevisiae
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Spinacia oleracea
2-oxoglutarate + NH3
-
288893
Spinacia oleracea
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Canis lupus familiaris
2-oxoglutarate + NH3
-
-
-
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Enterococcus faecalis
2-oxoglutarate + NH3
-
288893
Enterococcus faecalis
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Embryophyta
2-oxoglutarate + NH3
-
288893
Embryophyta
?
2-oxoglutaramate + H2O
alpha-ketoglutaramate
288893
Lactuca sativa
2-oxoglutarate + NH3
-
288893
Lactuca sativa
?
2-oxosuccinamate + H2O
alpha-ketosuccinamate
288893
Rattus norvegicus
2-oxosuccinate + NH3
-
-
-
?
2-oxosuccinamate + H2O
open-chain form
288893
Rattus norvegicus
2-oxosuccinate + NH3
-
-
-
?
ethyl glutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
ethyl succinate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
gamma-ethyl 2-oxoglutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
gamma-ethyl 2-oxoglutarate + methylamine
gamma-ethyl alpha-ketoglutarate
288893
Rattus norvegicus
?
-
-
-
?
gamma-methyl 2-oxoglutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
glutaramate + H2O
-
288893
Rattus norvegicus
glutarate + NH3
-
-
-
?
glutaramate + hydroxylamine
hydroxaminolysis
288893
Rattus norvegicus
glutaryl hydroxamate + NH3
-
-
-
?
methyl glutarate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
methyl succinate + methylamine
methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
additional information
no hydrolysis of asparagine and glutamine
288893
Rattus norvegicus
?
-
-
-
?
additional information
catalyzes methylamide formation
288893
Rattus norvegicus
?
-
-
-
?
additional information
catalyzes hydroxaminolysis and transamidation reactions with esters and amides
288893
Rattus norvegicus
?
-
-
-
?
additional information
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
288893
Homo sapiens
?
-
-
-
?
additional information
enzyme of glutamine-transaminase-omega-amidase pathway, role in degradation of glutamine
288893
Rattus norvegicus
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Mus musculus
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Homo sapiens
?
-
-
-
?
additional information
second enzyme of the enzyme system capable of converting glutamine to ammonia and capable of generating relatively large amounts of ammonia from glutamine, the glutaminase II pathway, glutamine transaminase, EC 2.6.1.15 plus omega-amidase, EC 3.5.1.3 pathway
288893
Rattus norvegicus
?
-
-
-
?
additional information
glutamine-transaminase-omega-amidase pathway, metabolic role: utilization of glutamine, formation of ammonia, ammoniagenesis, and utilization of certain alpha-keto acids for synthesis of corresponding amino acids
288893
Rattus norvegicus
?
-
-
-
?
N-methyl-2-oxoglutaramate + H2O
at a slow rate
288893
Rattus norvegicus
2-oxoglutarate + methylamine
-
288893
Rattus norvegicus
?
N-methyl-2-oxoglutaramate + H2O
N-methyl-alpha-ketoglutaramate
288893
Rattus norvegicus
2-oxoglutarate + methylamine
-
288893
Rattus norvegicus
?
succinamate + H2O
-
288893
Rattus norvegicus
succinic acid + NH3
-
-
-
?
succinamate + hydroxylamine
hydroxaminolysis
288893
Rattus norvegicus
succinyl hydroxamate + NH3
-
-
-
r
succinyl hydroxamate + H2O
-
288893
Rattus norvegicus
succinate + hydroxylamine
-
-
-
r
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
liver, 2 * 27000-28000, two subunits may be nonidentical, high-speed sedimentation equilibrium in the presence of 7 M guanidine hydrochloride or 7 M urea containing 0.1 M 2-mercaptoethanol
Rattus norvegicus
Temperature Stability [°C] (protein specific)
Temperature Stability Minimum [°C]
Temperature Stability Maximum [°C]
Commentary
Organism
additional information
-
-
Rattus norvegicus
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
additional information
-
-
Rattus norvegicus
6.5
9.5
broad pH-optimum, hydrolysis of alpha-ketosuccinamate
Rattus norvegicus
9
-
hydrolysis of alpha-ketoglutaramate, sharp maximum
Rattus norvegicus
pH Stability (protein specific)
pH Stability
pH Stability Maximum
Commentary
Organism
additional information
-
-
Rattus norvegicus
Other publictions for EC 3.5.1.3
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
752906
Hariharan
The enzymology of 2-hydroxygl ...
Homo sapiens
Biology
6
E24
2017
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
4
-
4
-
4
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
4
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
755020
Ellens
Evidence that glutamine trans ...
Solanum lycopersicum, Zea mays
Phytochemistry
113
160-169
2015
-
-
3
-
-
-
-
3
2
-
-
3
-
18
-
-
3
-
-
-
-
-
12
-
3
-
-
-
3
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
3
2
-
-
3
-
-
-
3
-
-
-
-
12
-
-
-
-
3
-
-
-
-
-
3
3
-
3
3
734871
Zhang
Identification and characteriz ...
Arabidopsis thaliana, Arabidopsis thaliana Col
Phytochemistry
99
36-43
2014
-
-
1
-
-
-
-
3
2
-
2
2
-
12
-
-
1
-
-
1
-
-
10
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
2
-
2
2
-
-
-
1
-
1
-
-
10
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
721018
Cobzaru
Homologous gene clusters of ni ...
Paenarthrobacter nicotinovorans, Rhodococcus opacus, Nocardioides sp., Nocardioides sp. JS614 / ATCC BAA-499
Res. Microbiol.
162
285-291
2011
-
-
2
-
-
-
-
-
-
-
-
4
-
8
-
-
-
-
-
-
-
-
5
-
-
3
-
-
-
3
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
5
-
3
-
-
-
3
-
-
-
-
6
6
-
-
-
710840
Krasnikov
Assay and purification of omeg ...
Rattus norvegicus
Anal. Biochem.
391
144-150
2009
-
1
-
-
-
-
-
-
4
-
1
-
-
10
-
-
1
-
-
4
2
-
2
-
1
1
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
1
-
-
-
-
1
-
4
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
711316
Jaisson
Molecular identification of om ...
Mus musculus
Biochimie
91
1066-1071
2009
-
-
1
-
-
-
-
8
-
-
-
-
-
12
-
-
1
-
-
1
-
-
6
-
-
1
-
-
8
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
8
-
-
-
-
-
-
-
1
-
1
-
-
6
-
1
-
-
8
2
-
-
-
-
-
-
-
8
8
711317
Krasnikov
Identification of the putative ...
Homo sapiens, Rattus norvegicus
Biochimie
91
1072-1080
2009
-
-
1
-
-
-
-
3
-
-
8
4
-
7
-
-
2
-
-
3
-
-
4
3
6
2
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
-
8
4
-
-
-
2
-
3
-
-
4
3
2
-
-
-
2
-
-
-
-
1
1
-
-
-
288890
Makar
Glutamine transaminase K and o ...
Gallus gallus, Homo sapiens, Mus musculus, Rattus norvegicus
J. Neurochem.
62
1983-1988
1994
-
-
-
-
-
-
-
-
-
-
-
8
-
16
-
-
-
-
-
25
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
-
25
-
-
8
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288891
Cooper
High activities of glutamine t ...
Rattus norvegicus
J. Neurochem.
61
1731-1741
1993
-
-
-
-
-
-
-
-
4
-
-
5
-
11
-
-
-
-
-
11
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
5
-
-
-
-
-
11
-
-
6
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
288884
Cooper
alpha-Keto acid omega-amidase ...
Saccharomyces cerevisiae, Embryophyta, Homo sapiens, Mus musculus, Rattus norvegicus
Methods Enzymol.
113
350-358
1985
-
3
-
-
-
2
8
3
5
1
2
8
-
9
1
-
1
1
1
14
2
2
24
1
-
-
-
3
-
2
-
-
-
-
-
-
-
3
-
-
-
-
2
-
8
-
3
5
1
2
8
-
1
-
1
1
14
2
2
24
1
-
-
3
-
2
-
-
-
-
-
-
-
-
-
288885
Calderon
omega-Amidase pathway in the d ...
Neurospora crassa
J. Bacteriol.
161
807-809
1985
-
-
-
-
-
-
3
-
-
-
-
2
-
3
-
-
-
-
-
-
2
-
2
-
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
1
-
-
-
1
-
-
-
-
-
-
-
-
-
288893
Cooper
The glutamine transaminase-ome ...
Saccharomyces cerevisiae, Canis lupus familiaris, Escherichia coli, Enterococcus faecalis, Embryophyta, Homo sapiens, Lactuca sativa, Mus musculus, Rattus norvegicus, Spinacia oleracea
CRC Crit. Rev. Biochem.
4
281-303
1977
-
-
-
-
-
-
-
-
3
-
1
11
-
11
-
-
1
1
-
20
-
-
36
1
-
-
-
1
-
3
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
11
-
-
-
1
-
20
-
-
36
1
-
-
1
-
3
-
1
-
-
-
-
-
-
-
288894
Cooper
The glutamine transaminase-ome ...
Homo sapiens, Rattus norvegicus
J. Neurochem.
28
771-778
1977
-
-
-
-
-
-
-
-
9
-
-
6
-
2
-
-
-
-
-
11
2
-
6
-
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
9
-
-
6
-
-
-
-
-
11
2
-
6
-
2
-
-
-
2
-
-
-
-
-
-
-
-
-
288886
Fernald
Purification and properties of ...
Bacillus subtilis, Thermus aquaticus, Bacillus subtilis 168, Thermus aquaticus YT-1
Arch. Biochem. Biophys.
153
95-104
1972
2
-
-
-
-
2
6
6
-
6
2
4
-
124
-
-
2
-
-
-
2
2
48
-
-
4
2
-
-
6
-
-
2
-
-
-
2
-
-
2
-
-
2
-
8
-
6
-
6
2
4
-
-
-
2
-
-
2
2
48
-
4
2
-
-
6
-
-
-
-
-
-
-
-
-
288887
Ramaley
Dicarboxylate omega-amidase of ...
Bacillus subtilis, Bacillus subtilis 168
Arch. Biochem. Biophys.
153
88-94
1972
3
-
-
-
-
-
1
-
3
-
-
-
-
102
-
-
1
-
-
-
1
-
4
-
-
1
-
-
-
-
-
-
-
-
-
-
3
-
-
-
-
-
-
-
2
-
-
3
-
-
-
-
-
-
1
-
-
1
-
4
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
288888
Hersh
Rat liver omega-amidase. Kinet ...
Rattus norvegicus
Biochemistry
11
2251-2256
1972
2
-
-
-
-
-
6
14
-
-
-
2
4
1
-
-
1
5
-
2
1
-
26
-
-
1
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
6
-
14
-
-
-
2
4
-
-
1
-
2
1
-
26
-
1
-
-
-
2
-
-
-
-
-
-
-
-
-
288892
Hersh
Rat liver omega-amidase. Purof ...
Rattus norvegicus
Biochemistry
10
2884-2891
1971
-
-
-
-
-
-
12
23
1
1
1
4
-
3
-
-
1
1
-
2
2
1
49
1
-
1
-
2
-
2
-
4
-
-
-
-
-
-
-
-
-
-
-
-
14
-
23
1
1
1
4
-
-
-
1
-
2
2
1
49
1
1
-
2
-
2
-
4
-
-
-
-
-
-
-
288889
Meister
Hydrolysis and transfer reacti ...
Rattus norvegicus
J. Biol. Chem.
215
441-460
1955
1
-
-
-
-
-
-
-
1
1
-
1
-
1
-
-
1
1
-
2
-
-
24
-
-
-
-
-
-
8
-
-
1
-
-
-
1
-
-
1
-
-
-
-
-
-
-
1
1
-
1
-
-
-
1
-
2
-
-
24
-
-
-
-
-
8
-
-
-
-
-
-
-
-
-