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Literature summary for 3.5.1.24 extracted from
- The enzymatic cleavage of the carbon-nitrogen bond in 3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-oylglycine (1967), J. Biol. Chem., 242, 7-11.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3,7,12-triketo-5beta-cholan-24-oylglycine | - |
Clostridium perfringens |  |
| 3,7,12-Triketo-5beta-cholanoic acid | - |
Clostridium perfringens | |
| cholic acid | competitive product inhibition | Clostridium perfringens | |
| Cu2+ | 0.3 mM, 45% inhibition | Clostridium perfringens | |
| Hg2+ | 0.0001 mM, 67% inhibition | Clostridium perfringens | |
| iodoacetate | - |
Clostridium perfringens | |
| PCMB | - |
Clostridium perfringens | |
| Zn2+ | 5 mM, 69% inhibition | Clostridium perfringens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.2 | - |
glycodeoxycholic acid | - |
Clostridium perfringens | |
| 3 | - |
taurochenodeoxycholic acid | - |
Clostridium perfringens | |
| 3.5 | - |
taurodeoxycholic acid | - |
Clostridium perfringens | |
| 3.6 | - |
glycocholic acid | - |
Clostridium perfringens | |
| 8 | - |
glycocholic acid | - |
Clostridium perfringens | |
| 14 | - |
glycochenodeoxycholic acid | - |
Clostridium perfringens | |
| 37 | - |
taurocholic acid | - |
Clostridium perfringens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Clostridium perfringens | - |
ATCC 19574, Sinai No. 43-F-4 | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 599.2 | - |
- |
Clostridium perfringens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, pH 7.0, stable for 8 weeks | Clostridium perfringens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3alpha,7alpha,12alpha-trihydroxy-5beta-homocholan-24-oyltaurine + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-homocholanate + taurine | - |
? | |
| glycochenodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| glycocholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + glycine | - |
? | |
| glycodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,12alpha-dihydroxy-5beta-cholanate + Gly | - |
? | |
| taurochenodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha-dihydroxy-5beta-cholanate + taurine | - |
? | |
| taurocholic acid + H2O | - |
Clostridium perfringens | 3alpha,7alpha,12alpha-trihydroxy-5beta-cholanate + taurine | - |
? | |
| taurodeoxycholic acid + H2O | - |
Clostridium perfringens | 3alpha,12alpha-dihydroxy-5beta-cholanate + taurine | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.6 | 5.8 | - |
Clostridium perfringens |
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