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Literature summary for 3.5.1.23 extracted from

  • Li, Y.; Chen, Q.; Yang, L.; Li, Y.; Zhang, Y.; Qiu, Y.; Ren, J.; Lu, C.
    Identification of highly potent N-acylethanolamine acid amidase (NAAA) inhibitors optimization of the terminal phenyl moiety of oxazolidone derivatives (2017), Eur. J. Med. Chem., 139, 214-221 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-(6-phenylhexanoyl)-1,3-oxazolidin-2-one above, pH and temperature not specified in the publication, 9.4% inhibition at 0.02 mM Rattus norvegicus
3-[4-(cyclohexyloxy)benzoyl]-1,3-oxazolidin-2-one above, pH and temperature not specified in the publication, 18.3% inhibition at 0.02 mM Rattus norvegicus
3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one above, pH and temperature not specified in the publication, 14.7% inhibition at 0.02 mM Rattus norvegicus
3-[6-(4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one above, pH and temperature not specified in the publication, 4.9% inhibition at 0.02 mM Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Rattus norvegicus 5764
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus Q6P7S1
-
-

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Rattus norvegicus
ASAH1
-
Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000009
-
above, pH and temperature not specified in the publication Rattus norvegicus 3-[6-(3-chlorophenyl)hexanoyl]-1,3-oxazolidin-2-one
0.000061
-
above, pH and temperature not specified in the publication Rattus norvegicus 3-[6-(4-hydroxyphenyl)hexanoyl]-1,3-oxazolidin-2-one
0.000092
-
above, pH and temperature not specified in the publication Rattus norvegicus 3-[4-(cyclohexyloxy)benzoyl]-1,3-oxazolidin-2-one
0.00027
-
above, pH and temperature not specified in the publication Rattus norvegicus 3-(6-phenylhexanoyl)-1,3-oxazolidin-2-one