Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.23 extracted from

  • Beckham, T.H.; Cheng, J.C.; Lu, P.; Marrison, S.T.; Norris, J.S.; Liu, X.
    Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling (2013), PLoS ONE, 8, e76593.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens Q13510
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation enzyme expression vector, recombinant enzyme Homo sapiens
-
DU-145 cell
-
 Homo sapiens
-
prostate
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
acid ceramidase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction leptomycin B prevents acid ceramidase and sphingosine 1-phosphate mediated loss of nuclear PTEN, suggesting an active exportin-mediated event Homo sapiens
physiological function tumor promotion of acid ceramidase in prostate cancer. Impact of acid ceramidase on the nuclear-cytoplasmic trafficking of tumor suppressor PTEN, immunohistochemical analysis, overview. Acid ceramidase, through sphingosine 1-phosphate, promotes nuclear export of PTEN as a means of promoting tumor formation, cell proliferation, and resistance to therapy. Acid ceramidase promotes a reduction in nuclear PTEN that is dependent upon sphingosine 1-phosphate-mediated activation of Akt Homo sapiens