Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Ceranib-1 | i.e. 3-(3-(4-methoxyphenyl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one | Homo sapiens | |
Ceranib-2 | i.e. 3-[3-(4-methoxyphenyl)acryloyl]-4-phenyl-1H-quinolin-2-one | Homo sapiens | |
D-NMAPPD | - |
Homo sapiens | |
additional information | DMAPP has no affect on ceramidase activity up to at least 0.3 mM. N-oleoylethanolamine has no affect on ceramidase activity | Homo sapiens | |
N-oleoylethanolamine | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | Homo sapiens | - |
sphingosine + fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SKOV-3 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | - |
Homo sapiens | sphingosine + fatty acid | - |
? | |
N-((2S,3R)-1,3-dihydroxy-5-((2-oxo-2H-chromen-7-yl)oxy)pentan-2-yl)palmitamide + H2O | - |
Homo sapiens | palmitate + 2-amino-2,4-dideoxy-5-O-(2-oxo-2H-chromen-7-yl)-D-erythro-pentitol | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.028 | - |
at 37°C, pH not specified in the publication | Homo sapiens | Ceranib-2 | |
0.055 | - |
at 37°C, pH not specified in the publication | Homo sapiens | Ceranib-1 |