Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.1.23 extracted from

  • Jenkins, R.W.; Clarke, C.J.; Canals, D.; Snider, A.J.; Gault, C.R.; Heffernan-Stroud, L.; Wu, B.X.; Simbari, F.; Roddy, P.; Kitatani, K.; Obeid, L.M.; Hannun, Y.A.
    Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase (2011), J. Biol. Chem., 286, 13292-13303.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Localization

Localization Comment Organism GeneOntology No. Textmining
endolysosome
-
 Homo sapiens 36019
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
FD-1 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-
NPD-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
aCDase
-
 Homo sapiens
acid ceramidase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction cells deficient in acid ceramidase exhibit defects in CCL5 transcriptional induction Homo sapiens
physiological function co-expression of acid sphingomyelinase and acid ceramidase is sufficient to strongly induce CCL5 transcription Homo sapiens