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Literature summary for 3.5.1.23 extracted from
- Acid ceramidase-mediated production of sphingosine 1-phosphate promotes prostate cancer invasion through upregulation of cathepsin B (2012), Int. J. Cancer, 131, 2034-2043.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in human prostate tissues, acid ceramidase and cathepsin B overexpression are strongly associated and may relate to poor outcome | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 13000 | - |
x * 13000, SDS-PAGE | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| DU-145 cell | - |
Homo sapiens | - |
| DuPro cell | - |
Homo sapiens | - |
| PC-3 cell | - |
Homo sapiens | - |
| PPC-1 cell | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 13000, SDS-PAGE | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acid ceramidase | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | acid ceramidase is overexpressed in most prostate tumors | up |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | acid ceramidase, through generation of sphingosine-1-phosphate, promotes an invasive phenotype in prostate cancer and promotes Ets1 nuclear expression and binding to the promoter region of matrix-degrading protease cathepsin B. Acid ceramidase overexpression promotes pericellular localization of cathepsin B and its translocation to the outer leaflet of the cell membrane | Homo sapiens |
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Release 2023.1 (January 2023)
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