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Literature summary for 3.5.1.23 extracted from

  • O’Neill, S.M.; Houck, K.L.; Yun, J.K.; Fox, T.E.; Kester, M.
    AP-1 binding transcriptionally regulates human neutral ceramidase (2011), Arch. Biochem. Biophys., 511, 31-39.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Homo sapiens
-
 sphingosine + fatty acid
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
coronary artery smooth muscle cell
-
 Homo sapiens
-
HEK-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
 Homo sapiens sphingosine + fatty acid
-
 ?

Synonyms

Synonyms Comment Organism
nCDase
-
 Homo sapiens
neutral ceramidase
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens treatment with fetal bovine serum (FBS) induces approximately a 60% increase in nCDase mRNA expression in coronary artery smooth muscle cells after 6 h. FBS elevates nCDase mRNA expression approximately 35% in HEK-293. cells c-Jun/AP-1 signaling in part regulates serum-induced human nCDase gene transcription up