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Literature summary for 3.5.1.23 extracted from

  • Novgorodov, S.A.; Wu, B.X.; Gudz, T.I.; Bielawski, J.; Ovchinnikova, T.V.; Hannun, Y.A.; Obeid, L.M.
    Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA (2011), J. Biol. Chem., 286, 25352-25362.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol inhibitor of alkaline ceramidase Mus musculus
D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol inhibitor of alkaline ceramidase Rattus norvegicus
N-oleoylethanolamine inhibitor of acid ceramidase Mus musculus
N-oleoylethanolamine inhibitor of acid ceramidase Rattus norvegicus
urea-hexanoyl-ceramide
-
Mus musculus
urea-hexanoyl-ceramide
-
Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-
mitochondrion
-
Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Mus musculus
-
sphingosine + fatty acid
-
?
ceramide + H2O Rattus norvegicus
-
sphingosine + fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
Mus musculus sphingosine + fatty acid
-
?
ceramide + H2O
-
Rattus norvegicus sphingosine + fatty acid
-
?
D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O
-
Mus musculus 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine
-
r
D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O
-
Rattus norvegicus 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine
-
r

Synonyms

Synonyms Comment Organism
nCDase
-
Mus musculus
nCDase
-
Rattus norvegicus
neutral ceramidase
-
Mus musculus
neutral ceramidase
-
Rattus norvegicus

General Information

General Information Comment Organism
physiological function neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo Mus musculus
physiological function neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo Rattus norvegicus