Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol | inhibitor of alkaline ceramidase | Mus musculus | |
D-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol | inhibitor of alkaline ceramidase | Rattus norvegicus | |
N-oleoylethanolamine | inhibitor of acid ceramidase | Mus musculus | |
N-oleoylethanolamine | inhibitor of acid ceramidase | Rattus norvegicus | |
urea-hexanoyl-ceramide | - |
Mus musculus | |
urea-hexanoyl-ceramide | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | Mus musculus | - |
sphingosine + fatty acid | - |
? | |
ceramide + H2O | Rattus norvegicus | - |
sphingosine + fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | - |
Mus musculus | sphingosine + fatty acid | - |
? | |
ceramide + H2O | - |
Rattus norvegicus | sphingosine + fatty acid | - |
? | |
D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O | - |
Mus musculus | 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine | - |
r | |
D-erythro-dodecanoyl-7-nitrobenz-2-oxa-1,3-diazol-4-yl-ceramide + H2O | - |
Rattus norvegicus | 12-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]dodecanoic acid + sphingosine | - |
r |
Synonyms | Comment | Organism |
---|---|---|
nCDase | - |
Mus musculus |
nCDase | - |
Rattus norvegicus |
neutral ceramidase | - |
Mus musculus |
neutral ceramidase | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo | Mus musculus |
physiological function | neutral ceramidase is a key participant of ceramide formation in liver mitochondria. The reverse activity of neutral ceramidase contributes to sphingolipid homeostasis in this organelle in vivo. The enzyme contributes to the overall ceramide profile of liver mitochondria at basal conditions in vivo | Rattus norvegicus |