Application | Comment | Organism |
---|---|---|
drug development | development of small molecule drugs, that inhibit AC enzyme activity, is a promising approach for improving standard cancer therapy and patient's clinical outcomes | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
acid ceramidase maps to 8p22, the region of chromosome 8 most frequently deleted in prostate cancer. Regulation of gene expression by acid ceramidase in prostate cancer cells, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a germ line single nucleotide polymorphism creates a splice site resulting in alternatively-spliced KLF6 isoforms, termed KLF6 SV1, SV2 and SV3. The splice variants show that SV1 has a counteracting effect on the wild-type KLF6 tumor suppressor activity, thus permitting tumor progression | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | predominantly | Homo sapiens | 5764 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | Homo sapiens | - |
sphingosine + fatty acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
prostate cancer cell | acid ceramidase upregulation in prostate cancer | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ceramide + H2O | - |
Homo sapiens | sphingosine + fatty acid | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | the 53 kDa acid ceramidase pre-polypeptide undergoes autocatalytic processing into two subunits of 13 and 40 kDa, respectively | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
acid ceramidase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | radiation-induced acid ceramidase upregulation confers resistance to taxane | up |
General Information | Comment | Organism |
---|---|---|
metabolism | ceramide metabolism, sphingolipid signaling, and aberrant ceramide signaling and cancer development, overview. Pathways of sphingolipid metabolism, overview | Homo sapiens |
additional information | human acid ceramidase deficiency is associated with Farber disease. It plays a role in androgen depletion therapy and in resistance to chemotherapy and to radiation therapy, overview | Homo sapiens |
physiological function | the enzyme is involved in ceramide metabolism and is a critical regulator of cancer cell growth and/or survival, acid ceramidase upregulation in prostate cancer plays a role in tumor development. A dysfunctional ceramide pathway is responsible for tumor progression and resistance to chemotherapy and radiation | Homo sapiens |