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Literature summary for 3.5.1.23 extracted from

  • Liu, X.; Cheng, J.C.; Turner, L.S.; Elojeimy, S.; Beckham, T.H.; Bielawska, A.; Keane, T.E.; Hannun, Y.A.; Norris, J.S.
    Acid ceramidase upregulation in prostate cancer: role in tumor development and implications for therapy (2009), Expert Opin. Ther. Targets, 13, 1449-1458.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
drug development development of small molecule drugs, that inhibit AC enzyme activity, is a promising approach for improving standard cancer therapy and patient's clinical outcomes Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
acid ceramidase maps to 8p22, the region of chromosome 8 most frequently deleted in prostate cancer. Regulation of gene expression by acid ceramidase in prostate cancer cells, overview Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information a germ line single nucleotide polymorphism creates a splice site resulting in alternatively-spliced KLF6 isoforms, termed KLF6 SV1, SV2 and SV3. The splice variants show that SV1 has a counteracting effect on the wild-type KLF6 tumor suppressor activity, thus permitting tumor progression Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome predominantly Homo sapiens 5764
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ceramide + H2O Homo sapiens
-
sphingosine + fatty acid
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
prostate cancer cell acid ceramidase upregulation in prostate cancer Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ceramide + H2O
-
Homo sapiens sphingosine + fatty acid
-
?

Subunits

Subunits Comment Organism
dimer the 53 kDa acid ceramidase pre-polypeptide undergoes autocatalytic processing into two subunits of 13 and 40 kDa, respectively Homo sapiens

Synonyms

Synonyms Comment Organism
acid ceramidase
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens radiation-induced acid ceramidase upregulation confers resistance to taxane up

General Information

General Information Comment Organism
metabolism ceramide metabolism, sphingolipid signaling, and aberrant ceramide signaling and cancer development, overview. Pathways of sphingolipid metabolism, overview Homo sapiens
additional information human acid ceramidase deficiency is associated with Farber disease. It plays a role in androgen depletion therapy and in resistance to chemotherapy and to radiation therapy, overview Homo sapiens
physiological function the enzyme is involved in ceramide metabolism and is a critical regulator of cancer cell growth and/or survival, acid ceramidase upregulation in prostate cancer plays a role in tumor development. A dysfunctional ceramide pathway is responsible for tumor progression and resistance to chemotherapy and radiation Homo sapiens