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Literature summary for 3.5.1.23 extracted from

  • Sun, W.; Hu, W.; Xu, R.; Jin, J.; Szulc, Z.M.; Zhang, G.; Galadari, S.H.; Obeid, L.M.; Mao, C.
    Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion (2009), FASEB J., 23, 656-666.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.1.23

Activating Compound

Activating Compound Comment Organism Structure
all-trans retinoic acid all-trans retinoic acid, ATRA, increases the expression of ACER2 in HeLa cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ACER2-specific siRNA
-
 Homo sapiens
phorbol myristate acetate phorbol myristate acetate, PMA, decreases the expression of ACER2 in HeLa cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens ceramidase catalyzes the hydrolysis of ceramide to form sphingosine ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information ceramidase catalyzes the hydrolysis of ceramide to form sphingosine Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
ACER2
-
 Homo sapiens
alkaline ceramidase 2
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 activity assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
9
-
 activity assay Homo sapiens