Any feedback?
Literature summary for 3.5.1.23 extracted from
- Involvement of neutral ceramidase in ceramide metabolism at the plasma membrane and in extracellular milieu (2005), J. Biol. Chem., 280, 36592-36600.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | doxorubicin induces enzyme expression | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of C-terminally myc-tagged enzyme in CHOP cells in endoplasmic reticulum and Golgi apparatus, as well as in plasma membranes | Mus musculus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | RNA interference gene silencing of the neutral CDase in mouse B16 cells leading to reduced enzyme activity and reduced levels of sphingosine and sphingosine 1-phosphate | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | subcellular localization, overview | Mus musculus | - |
- |
| plasma membrane | partially located in the extracellular space | Mus musculus | 5886 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Mus musculus | the enzyme is involved in ceramide metabolism at the plasma membrane and in extracellular milieu, hydrolysis of ceramide on the cell surface, overview, involvement of the enzyme in stimulus-induced Cer metabolism by doxorubicin | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrobenzo-2-oxa-1,3-diazole-C12-ceramide + H2O | - |
Mus musculus | 4-nitrobenzo-2-oxa-1,3-diazole-dodecanoic acid + ceramide | - |
? | |
| additional information | the enzyme is involved in ceramide metabolism at the plasma membrane and in extracellular milieu, hydrolysis of ceramide on the cell surface, overview, involvement of the enzyme in stimulus-induced Cer metabolism by doxorubicin | Mus musculus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| neutral CDase | - |
Mus musculus |
| neutral ceramidase | - |
Mus musculus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
