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Literature summary for 3.5.1.23 extracted from
- Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling (2005), J. Biol. Chem., 280, 20148-20153.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| functional overexpression of N-terminally C-myc-tagged enzyme, residues 1-1218, in 293T cells using a retroviral vector, in cell culture supernatant, recombinant retrovirus from 293T cell supernatant is used to infect C2C12 myoblasts | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | no accumulation of diacylglycerol occurs due to overexpression of the recombinant enzyme in myoblasts, but the recombinant enzyme prevents the inhibition of insulin signaling by palmitate in C1c12 myotubes, overview | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | diacylglycerol assay, i.e. ceramide:DAG assay | Homo sapiens | ? | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AC | - |
Homo sapiens |
| acid ceramidase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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