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Literature summary for 3.5.1.23 extracted from
- Subcellular localization of human neutral ceramidase expressed in HEK293 cells (2005), Biochem. Biophys. Res. Commun., 331, 37-42.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of the N-terminally GFP-tagged enzyme lacking the 19 amino acid N-terminal extension in HEK-293 and MCF7 cells exclusively in mitohcondria, expression of the longer enzyme version cloned from kidney resulted in localization of the recombinant enzyme in the plasma membrane of HEK-293 cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| additional information | subcellular localization, overview | Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9NR71 | N-CDase | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| kidney | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrobenzo-2-oxa-1,3-diazole-C12-ceramide + H2O | - |
Homo sapiens | 4-nitrobenzo-2-oxa-1,3-diazole-dodecanoic acid + ceramide | - |
? |  |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CDase | - |
Homo sapiens |
| N-CDase | - |
Homo sapiens |
| neutral ceramidase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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