Cloned (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
- |
Streptococcus pneumoniae |
- |
Caenorhabditis elegans |
- |
Plasmodium falciparum |
- |
Borreliella burgdorferi |
Protein Variants | Comment | Organism |
---|---|---|
C136A | the mutant is unable to catalyze nicotinamide hydrolysis | Streptococcus pneumoniae |
C136S | the mutant is unable to catalyze nicotinamide hydrolysis | Streptococcus pneumoniae |
K103A | the mutant has only 0.15% of the catalytic activity of the native enzyme | Streptococcus pneumoniae |
R97A | the mutant is a robust nicotinamidase and is nearly as good as the native enzyme | Streptococcus pneumoniae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-chloropyridine-3-carbaldehyde | - |
Borreliella burgdorferi | |
2-chloropyridine-3-carbaldehyde | - |
Saccharomyces cerevisiae | |
3-acetylpyridine | - |
Borreliella burgdorferi | |
3-acetylpyridine | - |
Plasmodium falciparum | |
3-acetylpyridine | - |
Saccharomyces cerevisiae | |
3-acetylpyridine | - |
Streptococcus pneumoniae | |
3-Cyanopyridine | - |
Borreliella burgdorferi | |
3-Cyanopyridine | - |
Plasmodium falciparum | |
3-Cyanopyridine | - |
Saccharomyces cerevisiae | |
3-Cyanopyridine | - |
Streptococcus pneumoniae | |
3-hydroxypyridine | - |
Streptococcus pneumoniae | |
4-methoxylnicotinaldehyde | weak inhibitor | Borreliella burgdorferi | |
4-methoxylnicotinaldehyde | weak inhibitor | Caenorhabditis elegans | |
4-methoxylnicotinaldehyde | weak inhibitor | Plasmodium falciparum | |
4-methoxylnicotinaldehyde | weak inhibitor | Saccharomyces cerevisiae | |
4-methoxylnicotinaldehyde | weak inhibitor | Streptococcus pneumoniae | |
5-bromopyridine-3-carbaldehyde | potent inhibitor | Plasmodium falciparum | |
5-bromopyridine-3-carbaldehyde | potent inhibitor | Saccharomyces cerevisiae | |
5-methoxypyridine-3-carbaldehyde | potent inhibitor | Borreliella burgdorferi | |
5-methoxypyridine-3-carbaldehyde | potent inhibitor | Caenorhabditis elegans | |
5-methoxypyridine-3-carbaldehyde | potent inhibitor | Plasmodium falciparum | |
5-methoxypyridine-3-carbaldehyde | potent inhibitor | Saccharomyces cerevisiae | |
5-methoxypyridine-3-carbaldehyde | potent inhibitor | Streptococcus pneumoniae | |
5-methylnicotinaldehyde | - |
Borreliella burgdorferi | |
5-methylnicotinaldehyde | - |
Caenorhabditis elegans | |
5-methylnicotinaldehyde | - |
Plasmodium falciparum | |
5-methylnicotinaldehyde | - |
Saccharomyces cerevisiae | |
5-methylnicotinaldehyde | - |
Streptococcus pneumoniae | |
5-methylpyridine-3-carbaldehyde | potent inhibitor | Borreliella burgdorferi | |
5-methylpyridine-3-carbaldehyde | potent inhibitor | Plasmodium falciparum | |
5-methylpyridine-3-carbaldehyde | potent inhibitor | Saccharomyces cerevisiae | |
6-fluoropyridine-3-carbaldehyde | - |
Borreliella burgdorferi | |
6-fluoropyridine-3-carbaldehyde | - |
Plasmodium falciparum | |
additional information | not inhibited by 3-hydroxypyridine | Borreliella burgdorferi | |
additional information | not inhibited by nicotinic acid | Caenorhabditis elegans | |
additional information | not inhibited by 3-hydroxypyridine and 2-chloropyridine-3-carbaldehyde | Plasmodium falciparum | |
additional information | not inhibited by 3-hydroxypyridine and 6-fluoropyridine-3-carbaldehyde | Saccharomyces cerevisiae | |
nicotinaldehyde | potent competitive inhibitor | Borreliella burgdorferi | |
nicotinaldehyde | potent competitive inhibitor | Caenorhabditis elegans | |
nicotinaldehyde | potent competitive inhibitor | Plasmodium falciparum | |
nicotinaldehyde | potent competitive inhibitor | Saccharomyces cerevisiae | |
nicotinaldehyde | potent competitive inhibitor | Streptococcus pneumoniae | |
nicotinic acid | - |
Borreliella burgdorferi | |
nicotinic acid | - |
Plasmodium falciparum | |
nicotinic acid | - |
Saccharomyces cerevisiae | |
nicotinic acid | - |
Streptococcus pneumoniae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0027 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
0.003 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.0106 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.0367 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.076 | - |
nicotinamide | wild type enzyme isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.113 | - |
nicotinamide | wild type enzyme isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methoxypyridine-3-carboxamide + H2O | Plasmodium falciparum | 12% activity compared to nicotinamide | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | Borreliella burgdorferi | 20% activity compared to nicotinamide | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | Saccharomyces cerevisiae | 5% activity compared to nicotinamide | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 6.5% activity compared to nicotinamide | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 137% activity compared to nicotinamide | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | Saccharomyces cerevisiae | 206% activity compared to nicotinamide | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | Borreliella burgdorferi | 221% activity compared to nicotinamide | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | Plasmodium falciparum | 646% activity compared to nicotinamide | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 163% activity compared to nicotinamide | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | Plasmodium falciparum | 330% activity compared to nicotinamide | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | Borreliella burgdorferi | 51% activity compared to nicotinamide | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | Saccharomyces cerevisiae | 80% activity compared to nicotinamide | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | Saccharomyces cerevisiae | 20% activity compared to nicotinamide | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 36% activity compared to nicotinamide | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | Plasmodium falciparum | 45% activity compared to nicotinamide | ? | - |
? | |
6-chloropyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 1.8% activity compared to nicotinamide | ? | - |
? | |
6-chloropyridine-3-carboxamide + H2O | Saccharomyces cerevisiae | 17% activity compared to nicotinamide | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | Streptococcus pneumoniae | 11% activity compared to nicotinamide | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | Plasmodium falciparum | 40% activity compared to nicotinamide | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | Borreliella burgdorferi | 45% activity compared to nicotinamide | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | Streptococcus pneumoniae | 0.86% activity compared to nicotinamide | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | Plasmodium falciparum | 2.3% activity compared to nicotinamide | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | Saccharomyces cerevisiae | 4.4% activity compared to nicotinamide | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | Saccharomyces cerevisiae | 15% activity compared to nicotinamide | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | Streptococcus pneumoniae | 3.5% activity compared to nicotinamide | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | Plasmodium falciparum | 6500% activity compared to nicotinamide | ? | - |
? | |
additional information | Saccharomyces cerevisiae | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | ? | - |
? | |
additional information | Plasmodium falciparum | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | ? | - |
? | |
additional information | Borreliella burgdorferi | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | ? | - |
? | |
additional information | Streptococcus pneumoniae | nicotinamidase cannot hydrolyze 1-methylisonicotinamide | ? | - |
? | |
additional information | Caenorhabditis elegans | nicotinamidase cannot hydrolyze 1-methylisonicotinamide | ? | - |
? | |
nicotinamide + H2O | Saccharomyces cerevisiae | 100% activity | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Streptococcus pneumoniae | 100% activity | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Caenorhabditis elegans | 100% activity | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Plasmodium falciparum | 100% activity | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | Borreliella burgdorferi | 100% activity | nicotinate + NH3 | - |
? | |
phenyl pyridine-3-carboxylate + H2O | Plasmodium falciparum | 13% activity compared to nicotinamide | ? | - |
? | |
phenyl pyridine-3-carboxylate + H2O | Saccharomyces cerevisiae | 3.1% activity compared to nicotinamide | ? | - |
? | |
phenyl pyridine-3-carboxylate + H2O | Streptococcus pneumoniae | 3.1% activity compared to nicotinamide | ? | - |
? | |
pyrazinamide + H2O | Saccharomyces cerevisiae | - |
pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | Streptococcus pneumoniae | - |
pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | Caenorhabditis elegans | - |
pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | Plasmodium falciparum | - |
pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | Borreliella burgdorferi | - |
pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyridine-3-carbothioamide + H2O | Saccharomyces cerevisiae | 44% activity compared to nicotinamide | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Borreliella burgdorferi | - |
- |
- |
Caenorhabditis elegans | - |
- |
- |
Plasmodium falciparum | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Saccharomyces cerevisiae |
- |
Streptococcus pneumoniae |
- |
Caenorhabditis elegans |
- |
Plasmodium falciparum |
- |
Borreliella burgdorferi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methoxypyridine-3-carboxamide + H2O | 12% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | 20% activity compared to nicotinamide | Borreliella burgdorferi | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | 5% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
4-methoxypyridine-3-carboxamide + H2O | 6.5% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | 137% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | 206% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | 221% activity compared to nicotinamide | Borreliella burgdorferi | ? | - |
? | |
5-methoxypyridine-3-carboxamide + H2O | 646% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | 163% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | 330% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | 51% activity compared to nicotinamide | Borreliella burgdorferi | ? | - |
? | |
5-methylpyridine-3-carboxamide + H2O | 80% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | 20% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | 36% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
6-aminopyridine-3-carboxamide + H2O | 45% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
6-chloropyridine-3-carboxamide + H2O | 1.8% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
6-chloropyridine-3-carboxamide + H2O | 17% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | 11% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | 40% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
6-methylpyridine-3-carboxamide + H2O | 45% activity compared to nicotinamide | Borreliella burgdorferi | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | 0.86% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | 2.3% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
ethyl pyridine-3-carboxylate + H2O | 4.4% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | 15% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | 3.5% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
methyl pyridine-3-carboxylate + H2O | 6500% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
additional information | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
additional information | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | Plasmodium falciparum | ? | - |
? | |
additional information | nicotinamidase cannot hydrolyze 1-methyl isonicotinamide | Borreliella burgdorferi | ? | - |
? | |
additional information | nicotinamidase cannot hydrolyze 1-methylisonicotinamide | Streptococcus pneumoniae | ? | - |
? | |
additional information | nicotinamidase cannot hydrolyze 1-methylisonicotinamide | Caenorhabditis elegans | ? | - |
? | |
nicotinamide + H2O | 100% activity | Saccharomyces cerevisiae | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | 100% activity | Streptococcus pneumoniae | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | 100% activity | Caenorhabditis elegans | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | 100% activity | Plasmodium falciparum | nicotinate + NH3 | - |
? | |
nicotinamide + H2O | 100% activity | Borreliella burgdorferi | nicotinate + NH3 | - |
? | |
phenyl pyridine-3-carboxylate + H2O | 13% activity compared to nicotinamide | Plasmodium falciparum | ? | - |
? | |
phenyl pyridine-3-carboxylate + H2O | 3.1% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? | |
phenyl pyridine-3-carboxylate + H2O | 3.1% activity compared to nicotinamide | Streptococcus pneumoniae | ? | - |
? | |
pyrazinamide + H2O | - |
Saccharomyces cerevisiae | pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | - |
Streptococcus pneumoniae | pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | - |
Caenorhabditis elegans | pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | - |
Plasmodium falciparum | pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyrazinamide + H2O | - |
Borreliella burgdorferi | pyrazine-2-carboxylic acid + NH3 | - |
? | |
pyridine-3-carbothioamide + H2O | 44% activity compared to nicotinamide | Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NIC | - |
Streptococcus pneumoniae |
NIC | - |
Plasmodium falciparum |
NIC | - |
Borreliella burgdorferi |
Pnc1 | - |
Saccharomyces cerevisiae |
Pnc1 | isoform | Caenorhabditis elegans |
PNC2 | isoform | Caenorhabditis elegans |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.003 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.28 | - |
nicotinamide | wild type enzyme isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.3 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
2.1 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
3.1 | - |
nicotinamide | wild type enzyme isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
3.8 | - |
nicotinamide | wild type enzyme, in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000011 | - |
nicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
0.000022 | - |
nicotinaldehyde | isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.000023 | - |
5-methylnicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.000023 | - |
5-methylpyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.000034 | - |
nicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.000039 | - |
5-methoxypyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.000056 | - |
5-methoxypyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
0.00011 | - |
nicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.00011 | - |
nicotinaldehyde | isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.00014 | - |
5-methoxypyridine-3-carbaldehyde | isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.00019 | - |
5-methylpyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.00031 | - |
5-methoxypyridine-3-carbaldehyde | isoform PNC1, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.00044 | - |
4-methoxylnicotinaldehyde | isoform PNC2, in 100 mM phosphate buffer, pH 7.3 at 25°C | Caenorhabditis elegans | |
0.00059 | - |
5-bromopyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.00065 | - |
5-methylpyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.00085 | - |
5-methoxypyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.001 | - |
4-methoxylnicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.0014 | - |
nicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.0038 | - |
5-methoxypyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.004 | - |
6-fluoropyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
0.004 | - |
5-bromopyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.018 | - |
6-fluoropyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.05 | - |
4-methoxylnicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
0.068 | - |
4-methoxylnicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.085 | - |
3-Cyanopyridine | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae | |
0.153 | - |
4-methoxylnicotinaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.37 | - |
2-chloropyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
0.5 | - |
3-Cyanopyridine | in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
1 | - |
3-Cyanopyridine | in 100 mM phosphate buffer, pH 7.3 at 25°C | Plasmodium falciparum | |
2 | - |
nicotinic acid | in 100 mM phosphate buffer, pH 7.3 at 25°C | Streptococcus pneumoniae | |
2 | - |
3-Cyanopyridine | in 100 mM phosphate buffer, pH 7.3 at 25°C | Borreliella burgdorferi | |
5 | - |
2-chloropyridine-3-carbaldehyde | in 100 mM phosphate buffer, pH 7.3 at 25°C | Saccharomyces cerevisiae |
General Information | Comment | Organism |
---|---|---|
physiological function | consistent with its centrality to NAD+ homeostasis, nicotinamidase is essential for viability | Saccharomyces cerevisiae |
physiological function | consistent with its centrality to NAD+ homeostasis, nicotinamidase is essential for viability | Streptococcus pneumoniae |
physiological function | consistent with its centrality to NAD+ homeostasis, nicotinamidase is essential for viability | Caenorhabditis elegans |
physiological function | consistent with its centrality to NAD+ homeostasis, nicotinamidase is essential for viability | Plasmodium falciparum |
physiological function | consistent with its centrality to NAD+ homeostasis, nicotinamidase is essential for viability | Borreliella burgdorferi |